Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility

DOI record: { "DOI": "10.1038/s41598-023-40999-5", "ISSN": [ "2045-2322" ], "URL": "http://dx.doi.org/10.1038/s41598-023-40999-5", "abstract": "<jats:title>Abstract</jats:title><jats:p>The mechanisms driving SARS-CoV-2 susceptibility remain poorly understood, especially the factors determining why unvaccinated individuals remain uninfected despite high-risk exposures. To understand lipid and metabolite profiles related with COVID-19 susceptibility and disease progression. We collected samples from an exceptional group of unvaccinated healthcare workers heavily exposed to SARS-CoV-2 but not infected (‘non-susceptible’) and subjects who became infected during the follow-up (‘susceptible’), including non-hospitalized and hospitalized patients with different disease severity providing samples at early disease stages. Then, we analyzed their plasma metabolomic profiles using mass spectrometry coupled with liquid and gas chromatography. We show specific lipids profiles and metabolites that could explain SARS-CoV-2 susceptibility and COVID-19 severity. More importantly, non-susceptible individuals show a unique lipidomic pattern characterized by the upregulation of most lipids, especially ceramides and sphingomyelin, which could be interpreted as markers of low susceptibility to SARS-CoV-2 infection. This study strengthens the findings of other researchers about the importance of studying lipid profiles as relevant markers of SARS-CoV-2 pathogenesis.</jats:p>", "alternative-id": [ "40999" ], "article-number": "15124", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "10 May 2023" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "20 August 2023" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "13 September 2023" }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 1, "value": "The authors declare no competing interests." } ], "author": [ { "affiliation": [], "family": "Albóniga", "given": "Oihane E.", "sequence": "first" }, { "affiliation": [], "family": "Moreno", "given": "Elena", "sequence": "additional" }, { "affiliation": [], "family": "Martínez-Sanz", "given": "Javier", "sequence": "additional" }, { "affiliation": [], "family": "Vizcarra", "given": "Pilar", "sequence": "additional" }, { "affiliation": [], "family": "Ron", "given": "Raquel", "sequence": "additional" }, { "affiliation": [], "family": "Díaz-Álvarez", "given": "Jorge", "sequence": "additional" }, { "affiliation": [], "family": "Rosas", "given": "Marta", "sequence": "additional" }, { "affiliation": [], "family": "Sánchez-Conde", "given": "Matilde", "sequence": "additional" }, { "affiliation": [], "family": "Galán", "given": "Juan Carlos", "sequence": "additional" }, { "affiliation": [], "family": "Angulo", "given": "Santiago", "sequence": "additional" }, { "affiliation": [], "family": "Moreno", "given": "Santiago", "sequence": "additional" }, { "affiliation": [], "family": "Barbas", "given": "Coral", "sequence": "additional" }, { "affiliation": [], "family": "Serrano-Villar", "given": "Sergio", "sequence": "additional" } ], "container-title": "Scientific Reports", "container-title-short": "Sci Rep", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2023, 9, 13 ] ], "date-time": "2023-09-13T09:02:15Z", "timestamp": 1694595735000 }, "deposited": { "date-parts": [ [ 2023, 9, 13 ] ], "date-time": "2023-09-13T10:10:42Z", "timestamp": 1694599842000 }, "funder": [ { "DOI": "10.13039/100009947", "award": [ "MISP# IIS 60257" ], "doi-asserted-by": "publisher", "name": "Merck Sharp and Dohme" }, { "DOI": "10.13039/501100004587", "award": [ "AC17/00019, PI18/00154, COV20/00349, ICI20/00058, PI21/00141" ], "doi-asserted-by": "publisher", "name": "Instituto de Salud Carlos III" }, { "DOI": "10.13039/501100015756", "award": [ "Mobility grant" ], "doi-asserted-by": "publisher", "name": "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" } ], "indexed": { "date-parts": [ [ 2023, 9, 14 ] ], "date-time": "2023-09-14T04:54:41Z", "timestamp": 1694667281067 }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2023, 9, 13 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2023, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 9, 13 ] ], "date-time": "2023-09-13T00:00:00Z", "timestamp": 1694563200000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 9, 13 ] ], "date-time": "2023-09-13T00:00:00Z", "timestamp": 1694563200000 } } ], "link": [ { "URL": "https://www.nature.com/articles/s41598-023-40999-5.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://www.nature.com/articles/s41598-023-40999-5", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://www.nature.com/articles/s41598-023-40999-5.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1038", "published": { "date-parts": [ [ 2023, 9, 13 ] ] }, "published-online": { "date-parts": [ [ 2023, 9, 13 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1126/science.abg6837", "author": "JP Wong", "doi-asserted-by": "publisher", "first-page": "884", "journal-title": "Science", "key": "40999_CR1", "unstructured": "Wong, J. 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