Risk factors predicting disease severity and mortality in coronavirus disease 2019 Saudi Arabian patients
Mohammed A Al Balwi, Wala M Al Balwi, Nouf Alghamdi, Reem Alshahrani, Ihssan H Abdelrahman, Sami Mahmoud, Ali Al-Hamad, Salma Al Hamzah, Fahad Al Jraid, Maha Al Turki
Annals of Thoracic Medicine, doi:10.4103/atm.atm_435_22
CONTEXT: Coronavirus disease 2019 (COVID-19) became a global pandemic that may be associated with significant associated risk factors.
AIMS: The aim of this study was to evaluate the factors predisposing risk to death in COVID-19 patients.
SETTINGS AND DESIGN: This is a retrospective study that presents the demographic, clinical presentation, and laboratory findings on our patients to determine risk factors contributing to their COVID-19 outcome.
METHODS: We used logistic regression (odds ratios) to examine associations between clinical findings and risk of death in COVID-19 patients. All analyses were done using STATA 15.
RESULTS: A total of 206 COVID-19 patients were investigated, 28 of them died, and 178 survived. Expired patients were older (74.04 ± 14.45 vs. 55.56 ± 18.41 in those who survived) and mainly of male gender (75% vs. 42% in those who survived). The following factors were strong
Ethical approval This study was approved by the Institutional Review Board (IRB) at King Abdullah International Medical Research Canter (SP21R/266/05).
Financial support and sponsorship
Nil.
Conflicts of interest There are no conflicts of interest.
References
Ahmed, Ahmed, Siddiqui, Rashid, Mansoor et al., Evaluation of serum ferritin for prediction of severity and mortality in COVID-19-A cross sectional study, Ann Med Surg (Lond)
Alguwaihes, Me, Megdad, Albader, Alsari et al., Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: A single-centre retrospective study, Cardiovasc Diabetol
Alzahrani, Jawdat, Alaskar, Cereb, Hajeer, ABO and Rh blood group genotypes in a cohort of Saudi stem cell donors, Int J Immunogenet
Balwi, Turki, Memish, Fakhoury, Balwi et al., Age/BMI is a stronger predictor of death in COVID-19 patients than age alone: A pilot study, J Epidemiol Glob Health
Behrens, Koretzky, Review: Cytokine storm syndrome: Looking toward the precision medicine era, Arthritis Rheumatol
Biswas, Khan, Coagulation disorders in COVID-19: Role of toll-like receptors, J Inflamm Res
Cucinotta, Vanelli, WHO declares COVID-19 a pandemic, Acta Biomed
Esposito, Cancro, Silverio, Maio, Iannece et al., COVID-19 and acute coronary syndromes: From pathophysiology to clinical perspectives, Oxid Med Cell Longev
Gil-Manso, Blanco, Motyka, Halpin, López-Esteban et al., ABO blood group is involved in the quality of the specific immune response anti-SARS-CoV-2, Virulence
Jawdat, Hajeer, Massadeh, Aljawini, Abedalthagafi et al., and the risk of COVID-19 infection and severity of disease in a Saudi Arabian Cohort, Annals of Thoracic Medicine
Kim, Kim, Ra, Lee, Bae et al., Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19, Clin Microbiol Infect
Munshi, Hussein, Toraih, Elshazli, Jardak et al., Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J Med Virol
Pereira, Felipe, De Freitas, Araújo, Soares et al., ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanisms, Microb Pathog
Pirzada, Mokhtar, Moeller, COVID-19 and myocarditis: What do we know so far?, CJC Open
Ratiani, Sanikidze, Ormotsadze, Pachkoria, Sordia, Role of ABO blood groups in susceptibility and severity of COVID-19 in the Georgian population, Indian J Crit Care Med
Samadizadeh, Masoudi, Rastegar, Salimi, Shahbaz et al., COVID-19: Why does disease severity vary among individuals, Respir Med
Singh, Gillies, Singh, Singh, Chudasama et al., Prevalence of co-morbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis, Diabetes Obes Metab
Tuffaha, Bcheraoui, Daoud, Hussaini, Alamri et al., Deficiencies under plenty of sun: Vitamin D status among adults in the kingdom of Saudi Arabia, N Am J Med Sci
Wong, Wong, Tang, Au, Wai, Clinical presentations, laboratory and radiological findings, and treatments for 11,028 COVID-19 patients: A systematic review and meta-analysis, Sci Rep
Zirpe, Pote, Deshmukh, Gurav, Tiwari et al., A retrospective analysis of risk factors of COVID-19 associated mucormycosis and mortality predictors: A single-Center study, Cureus
