Vitamin D levels and disease severity in COVID-19
Alarslan et al., Medical Journal of İzmir Hospital, 26:3
Alarslan et al., Vitamin D levels and disease severity in COVID-19, Medical Journal of İzmir Hospital, 26:3
Retrospective 153 COVID-19 patients in Turkey, showing lower age-adjusted vitamin D levels in hospitalized patients vs. outpatients.
Alarslan et al., 31 Jul 2022, retrospective, Turkey, peer-reviewed, 5 authors.
Abstract: Araştırma Makalesi / Research Article
İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi (Medical Journal of İzmir Hospital) 26 (3): 311-318, 2022
VITAMIN D LEVELS AND DISEASE SEVERITY IN COVID-19
COVID-19'DA D VİTAMİNİ DURUMU VE HASTALIK ŞIDDETİ
Pinar ALARSLAN1
Esin CELIKER2
Zeliha ARSLAN2
3
Gokcen UNAL KOCABAS
Oguzhan OZYURTKAN4
1
Department of Endocrine And Metabolic Diseases, Medicana International Istanbul Hospital,
Istanbul, Turkey
2
Department of Chest Diseases, Medicana International Istanbul Hospital, Istanbul, Turkey
3
Department of Endocrine And Metabolic Diseases, Izmir Baskent University Hospital, Izmir, Turkey
4
Department of Thoracic Surgery, Medicana International Istanbul Hospital, Istanbul, Turkey
Keywords: Covid-19, SARS-CoV2, vitamin D
Anahtar Sözcükler: Covid-19, SARS-CoV2, D vitamini
Yazının alınma tarihi: 21.10.2021
Yazının kabul tarihi: 15.03.2022
Online basım: 31.07.2022
SUMMARY
Introduction: to evaluate the clinical and biochemical characteristics of patients with Covid-19 with regard to
disease severity, and to assess vitamin D levels.
Material and methods: A total of 153 patients diagnosed with Covid-19 were enrolled in this retrospective cohort
study. Patients were divided into following three groups in terms of clinical severity: those managed as outpatients
(n=75), those managed in wards (n=61) and those requiring intensive care unit (ICU) (n=17).
Results: The levels of WBC, neutrophil, BUN, CRP, AST, ALT, D-dimer, ferritin, procalcitonin and BNP were
significantly higher in the intensive care group compared to ward patients and outpatients. Albumin levels,
hemoglobin values and lymphocyte percentages were lower in the severe disease group compared to the other
two groups. Estimated marginal means of the adjusted vitamin D levels were 14.32 ± 1.26 ng/mL for the
inpatients (ward and ICU) and 18.30±1.28 ng/mL for the outpatients (p=0.032).
Conclusion: Vitamin D deficiency may have been effective on the aggravation or prognosis of the disease,
possibly with its anti-inflammatory, anti-fibrotic, anti-oxidant and immunomodulatory effects. In this respect, the
role of vitamin D supplementation on treatment should be examined in further studies by monitoring vitamin D
levels in patients.
ÖZ
Giriş: Covid-19'lu hastaların klinik ve biyokimyasal özelliklerini hastalık şiddetine göre değerlendirmek ve D
vitamini düzeylerini değerlendirmek.
Gereç ve Yöntem: Bu retrospektif kohort çalışmasına Covid-19 tanısı konan toplam 153 hasta dahil edildi.
Hastalar klinik şiddet açısından şu şekilde üç gruba ayrıldı: ayakta tedavi gören hastalar (n = 75), servislerde
tedavi edilenler (n = 61) ve yoğun bakım ünitesi (YBÜ) gerektirenler (n = 17).
Bulgular: Yoğun bakım grubunda WBC, nötrofil, BUN, CRP, AST, ALT, D-dimer, ferritin, prokalsitonin ve BNP
düzeyleri serviste ve ayakta tedavi gören hastalara göre anlamlı olarak yüksekti. Şiddetli hastalık grubunda
albümin düzey, hemoglobin değeri ve lenfosit yüzdesi diğer iki gruba göre daha düşüktü. Düzeltilmiş D vitamini
311
düzeylerinin tahmini marjinal ortalamaları yatan hastalar (servis ve YBÜ) için 14.32 ± 1.26 ng / mL ve ayakta
tedavi gören hastalar için 18.30 ± 1.28 ng / mL idi (p = 0.032).
Sonuç: D vitamini eksikliği, muhtemelen anti-enflamatuar, anti-fibrotik, anti-oksidan ve immünomodülatör
etkileriyle hastalığın şiddetlenmesi ya prognozu üzerinde etkin olmuş olabilir. Bu açıdan hastalarda D vit düzeyi
takibi yapılarak ileri çalışmalarda D vit takviyesinin tedavi üzerindeki..
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