VITAMIN D LEVELS AND DISEASE SEVERITY IN COVID-19 COVID-19'DA D VİTAMİNİ DURUMU VE HASTALIK ŞIDDETİ
Araştırma Makalesi, Pinar Alarslan, Esin Celiker, Zeliha Arslan
Introduction: to evaluate the clinical and biochemical characteristics of patients with with regard to disease severity, and to assess vitamin D levels. were enrolled in this retrospective cohort study. Patients were divided into following three groups in terms of clinical severity: those managed as outpatients (n=75), those managed in wards (n=61) and those requiring intensive care unit (ICU) (n=17).
Material and methods: A total of 153 patients diagnosed with
Results: The levels of WBC, neutrophil, BUN, CRP, AST, ALT, D-dimer, ferritin, procalcitonin and BNP were significantly higher in the intensive care group compared to ward patients and outpatients. Albumin levels, hemoglobin values and lymphocyte percentages were lower in the severe disease group compared to the other two groups. Estimated marginal means of the adjusted vitamin D levels were 14.32 ± 1.26 ng/mL for the inpatients (ward and ICU) and 18.30±1.28 ng/mL for the outpatients (p=0.032).
Conclusion: Vitamin D deficiency may have been effective on the aggravation or prognosis of the disease, possibly with its anti-inflammatory, anti-fibrotic, anti-oxidant and immunomodulatory effects. In this respect, the role of vitamin D supplementation on treatment should be examined in further studies by monitoring vitamin D levels in patients.
ÖZ Giriş: Covid-19'lu hastaların klinik ve biyokimyasal özelliklerini hastalık şiddetine göre değerlendirmek ve D vitamini düzeylerini değerlendirmek.
Corresponding Author Pinar ALARSLAN (MD) Department of Endocrine And Metabolic Diseases, Medicana International Istanbul Hospital, Beylikduzu Cd. No: 3, 34520 Beylikduzu/Istanbul, Turkey Phone: +905052714605 E-mail: pinaralarslan@hotmail.com, ORCID: 0000-0003-1790-0796 Pinar ALARSLAN (MD) ORCID: 0000-0003-1790-0796 Esin CELIKER (MD) ORCID: 0000-0001-7530-0647 Zeliha ARSLAN (Assoc. Prof.) ORCID: 0000-0002-1022-3406 Gokcen UNAL KOCABAS (MD) ORCID: 0000-0002-1849-3179 Oguzhan OZYURTKAN (Prof. Dr.) ORCID: 0000-0003-2754-2080S
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