Association between serum vitamins and COVID-19 infection: a cross-sectional study of healthcare workers in a Nigerian tertiary hospital

Adetunji et al., BMC Infectious Diseases, doi:10.1186/s12879-026-12959-7, Feb 2026
Vitamin C for COVID-19
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Cross-sectional study of 181 healthcare workers showing significantly lower serum levels of most vitamins (A, C, D, E, and B-complex vitamins except B12) in those with COVID-19 infection compared to uninfected controls. Authors hypothesize that these vitamin deficiencies may increase susceptibility to COVID-19 infection through impaired immune function, as these micronutrients are essential for immune modulation, antioxidant defense, and maintaining barrier integrity.
Study covers vitamin C, vitamin A, vitamin D, vitamin B12, and vitamin B9.
Adetunji et al., 28 Feb 2026, Nigeria, peer-reviewed, survey, 11 authors, study period February 2022 - March 2022. Contact: taadetunji@oauife.edu.ng, jejesola16@yahoo.com, linktopeojo@yahoo.com, smithfemi@outlook.com, olarewajuolusolajoseph@gmail.com, badeakanji@gmail.com, sholex111@gmail.com, taiwo.olumakinde@uniosun.edu.ng, waidi.sule@uniosun.edu.ng, akindesb@uniosun.edu.ng, bolarinwaraa@yahoo.co.uk.
Association between serum vitamins and COVID-19 infection: a cross-sectional study of healthcare workers in a Nigerian tertiary hospital
Tajudin Adesegun Adetunji, Olusola Akanni Jeje, Temitope Olumuyiwa Ojo, Olufemi Samuel Smith, Olusola Joseph Olarewaju, Baderinwa Opeyemi Akanji, Olusola Fajobi, Taiwo Samson Olumakinde, Waidi Folorunso Sule, Sunday Babatunde Akinde, Rahman Ayodele Bolarinwa
BMC Infectious Diseases, doi:10.1186/s12879-026-12959-7
PRESS 7.74 ng/mL, p < 0.001), B6 (18.31 ng/mL vs. 25.02 ng/mL, p < 0.001), B9 (11.34 ng/mL vs. 13.92 ng/mL, p = 0.002), and C (0.63 mg/dL vs. 0.78 mg/dL, p = 0.007). Vitamins K and B12 were not significantly different between the two groups. Conclusions: This study identified an association between lower serum levels of fat-soluble vitamins A, D, and E, and most water-soluble vitamins with COVID-19 infection in healthcare workers. While further research is needed, these findings suggest the potential usefulness of micronutrient intervention to reduce vulnerability to COVID-19 and related infections.
Ethics Approval and Consent to Participate The ethical approval to conduct the study was obtained from the Ethics Consent for Publication Not applicable Competing interests The authors declare that they have no competing interests. Author contributions
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Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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