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Effectiveness of Zinc and ROS on Testosterone Hormone Levels forRecovering COVID-19 Patients

Abbas et al., Biochemical and Cellular Archives, 22:1
Apr 2023  
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Zinc for COVID-19
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Analysis of 70 recovered COVID-19 patients and 50 controls in Iraq, showing significantly lower zinc levels in COVID-19 patients.
Abbas et al., 1 Apr 2023, Iraq, peer-reviewed, 3 authors.
This PaperZincAll
AI generated summary. Current AI models can provide useful summaries for non-experts, but may be inaccurate and have limited ability to analyze larger context such as the entire evidence base for zinc.

Men who have recovered from COVID-19 have lower levels of zinc and testosterone than men who have not been infected with the virus.

  • COVID-19 is a respiratory illness caused by the SARS-CoV-2 virus.
  • The virus enters the body through the ACE2 receptor, which is found in high levels in the testes.
  • COVID-19 can damage the testes and lead to low testosterone levels.
  • Zinc is an essential mineral that is important for immune function and testosterone production.
  • ROS (reactive oxygen species) are molecules that can damage cells.
  • The study found that men with COVID-19 had lower levels of zinc and higher levels of ROS than men who were not infected with the virus.
  • The study also found that men with COVID-19 had lower testosterone levels than men who were not infected with the virus.
  • The study concluded that zinc supplementation may help to improve testosterone levels in men who have recovered from COVID-19.

The study was conducted on 120 men, 70 of whom had recovered from COVID-19 and 50 of whom had not been infected with the virus. The researchers measured the levels of zinc, ROS, and testosterone in all of the men. They found that the men who had recovered from COVID-19 had lower levels of zinc and higher levels of ROS than the men who had not been infected with the virus. They also found that the men who had recovered from COVID-19 had lower testosterone levels than the men who had not been infected with the virus.

The researchers concluded that zinc supplementation may help to improve testosterone levels in men who have recovered from COVID-19. They suggested that further studies are needed to confirm these findings.

Effectiveness of Zinc and ROS on Testosterone Hormone Levels for Recovering COVID-19 Patients
Adnan Mays, Abbas, Dr Nadia M M Al-Shakir
Background: COVID-19 (coronavirus disease 2019), cause severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) across all age groups, it's a positive-sense singlestranded RNA virus, and a member of the Betacoronavirus genus taxonomically (Jiang et al, 2020) . Given the importance roles of zinc in combating oxidative damage and viral infections, Zinc also has confirmed roles in both male and female reproduction. The possible depletion of zinc with the oxidative events of COVID-19 is especially relevant to the fertility of affected couples (Sethuram et al, 2021) . Aim of study: Is to determine the relation between Zinc value and oxidative stress level represented by ROS (Reactive Oxygen Species) and testosterone level among the recovered COVID-19 patients in reproductive age.
Abobaker, Raba, Does COVID-19 affect male fertility, World J Urol
Aboelnaga, Abdelrazek, Abdullah, El Shaer, Late Impact of COVID-19 Pneumonia on Testosterone Levels in Recovered, Post-Hospitalized Male Patients, Journal of Endocrinology and Metabolism
Carrillo, Izquierdo-Useros, Ávila-Nieto, Pradenas, Clotet et al., Humoral immune responses and neutralizing antibodies against SARS-CoV-2; implications in pathogenesis and protective immunity, Biochemical and biophysical research communications
Choe, Kim, Kang, Suh, Kang et al., Antibody Responses One Year after Mild SARS-CoV-2 Infection, Journal of Korean medical science
Delgado-Roche, Mesta, Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection, Archives of medical research
Douglas, O'bryan, Hedger, Lee, Yarski et al., The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis, Endocrinology
Elham, Azam, Azam, Mostafa, Nasrin et al., Serum vitamin D, calcium, and zinc levels in patients with COVID-19, Clinical Nutrition ESPEN
Jiang, Xia, Ying, Lu, A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome, Cellular & molecular immunology
Kadihasanoglu, Aktas, Yardimci, Aral, Kadioglu, SARS-CoV-2 Pneumonia affects male reproductive hormone levels: A prospective, cohort study, The Journal of Sexual Medicine
Lü, Lin, Yao, Chen, Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems, Journal of cellular and molecular medicine
Marie-Pierrette, COVID-19 infection and oxidative stress: an under-explored approach for prevention and treatment?, The Pan African Medical Journal
Molnar, Gair, Chapter 23.2. Adaptive Immune Response
Nag, Chaudhry, Mishra, Rai, Gupta, A prospective study on rapidly declining SARS-CoV-2 IgG antibodies within one to three months of testing IgG positive: can it lead to potential reinfections?, Cureus
Nassar, Leslie, Physiology, testosterone
Okçelik, COVID-19 pneumonia causes lower testosterone levels, Andrologia
Prasad, Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging, Journal of Trace Elements in Medicine and Biology
Rahman, Islam, Rahman, Alamin, Neurobiochemical cross-talk between COVID-19 and Alzheimer's disease, Molecular Neurobiology
Salonia, Pontillo, Capogrosso, Gregori, Tassara et al., Severely low testosterone in males with COVID-19: A case-control study
Sethuram, Bai, Abu-Soud, Potential role of zinc in the COVID-19 disease process and its probable impact on reproduction, Reproductive Sciences
Shen, Xiao, Aierken, Yue, Wu et al., The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection, Journal of cellular and molecular medicine
Smith, Walker, The regulation of spermatogenesis by androgens, Seminars in cell & developmental biology
Velthuis, Van Den Worm, Sims, Baric, Snijder et al., Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLoS pathogens
Wang, Xu, scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells, Cells
Wessels, Rolles, Rink, The potential impact of zinc supplementation on COVID-19 pathogenesis, Frontiers in immunology
Xu, Wang, Feng, Yu, Chen et al., Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients, Andrology
Yang, Chen, Huang, Zhong, Su et al., Pathological findings in the testes of COVID-19 patients: clinical implications, European urology focus
Zhang, Rong, Li, Flaviviridae viruses and oxidative stress: implications for viral pathogenesis. Oxidative medicine and cellular longevity
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