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Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men.
Yeap et al., European Journal of Endocrinology, doi:10.1530/EJE-22-0104
Yeap et al., Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men., European Journal of Endocrinology, doi:10.1530/EJE-22-0104
May 2022   Source   PDF  
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Prospective UK Biobank study showing higher premorbid testosterone levels associated with higher COVID-19 mortality.
Yeap et al., 10 May 2022, prospective, United Kingdom, peer-reviewed, 8 authors, study period 16 March, 2020 - 31 January, 2021.
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Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men. Authors
MBBS Bu B Yeap, Ross J Marriott, Laurens Manning, Girish Dwivedi, Graeme J Hankey, Frederick C W Wu, PhD Jeremy K Nicholson, Kevin Murray
Objective Men are at greater risk from COVID-19 than women. Older, overweight men, and those with type 2 diabetes, have lower testosterone concentrations, and poorer COVID-19-related outcomes. We analysed associations of premorbid serum testosterone concentrations, not confounded by effects of acute SARS-CoV-2 infection, with COVID-19-related mortality risk in men. Design UK Biobank prospective cohort study of community-dwelling men aged 40-69 years. Methods
Supplemental data Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men. Authors: Bu B. Yeap, Ross J. Marriott, Laurens Manning, Girish Dwivedi, Graeme J. Hankey, Frederick C.W. Wu, Jeremy K. Nicholson, Kevin Murray Supplemental Methods Variables of interest Social, demographic, and lifestyle variables Educational attainment (qualifications) was categorised as below A-levels (high school), completed A-levels, completed college/university, or completed other professional qualification (not school/college/university). Townsend Deprivation Index scores were grouped into quintile categories, with Quintile 5 being the most disadvantaged. 1 Alcohol consumption was categorised using a simplification of categories used by Topiwala et al.: "low" (<14 units/week) including abstainers and men with safe levels of consumption, consistent with UK guidelines; "medium" (14-<30 units/week); "high" ≥30 units/week (1 unit=8 g pure alcohol). 2, 3 Diet categories were high red meat (beef, lamb and pork >3 times/week), low red meat (≤3/week), no red meat, which is a simplification of Bradbury et al. 4 Ethnicity categories were White or Not white (includes Asian, Black, Chinese, Mixed, Other). Vigorous and moderate physical activity undertaken per week was categorised to World Health Organization recommendations as sufficient: ≥75 minutes vigorous or ≥150 minutes moderate, or equivalent combination; insufficient: less..
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