Let fever do its job

{ 'indexed': {'date-parts': [[2024, 1, 9]], 'date-time': '2024-01-09T11:45:22Z', 'timestamp': 1704800722817}, 'reference-count': 111, 'publisher': 'Oxford University Press (OUP)', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2020, 11, 23]], 'date-time': '2020-11-23T00:00:00Z', 'timestamp': 1606089600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'funder': [{'name': 'Polish Minister of Science and Higher Education', 'award': ['008/RID/2018/19']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 2, 26]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Although fever is one of the main presenting ' 'symptoms of COVID-19 infection, little public attention has been given to fever as an evolved ' 'defense. Fever, the regulated increase in the body temperature, is part of the evolved ' 'systemic reaction to infection known as the acute phase response. The heat of fever augments ' 'the performance of immune cells, induces stress on pathogens and infected cells directly, and ' 'combines with other stressors to provide a nonspecific immune defense. Observational trials ' 'in humans suggest a survival benefit from fever, and randomized trials published before ' 'COVID-19 do not support fever reduction in patients with infection. Like public health ' 'measures that seem burdensome and excessive, fevers involve costly trade-offs but they can ' 'prevent infection from getting out of control. For infections with novel SARS-CoV-2, the ' 'precautionary principle applies: unless evidence suggests otherwise, we advise that fever ' 'should be allowed to run its course.</jats:p><jats:p>Lay summary: For COVID-19, many public ' 'health organizations have advised treating fever with medicines such as acetaminophen or ' 'ibuprofen. Even though this is a common practice, lowering body temperature has not improved ' 'survival in laboratory animals or in patients with infections. Blocking fever can be harmful ' 'because fever, along with other sickness symptoms, evolved as a defense against infection. ' 'Fever works by causing more damage to pathogens and infected cells than it does to healthy ' 'cells in the body. During pandemic COVID-19, the benefits of allowing fever to occur probably ' 'outweigh its harms, for individuals and for the public at large.</jats:p>', 'DOI': '10.1093/emph/eoaa044', 'type': 'journal-article', 'created': { 'date-parts': [[2020, 11, 11]], 'date-time': '2020-11-11T12:10:03Z', 'timestamp': 1605096603000}, 'page': '26-35', 'source': 'Crossref', 'is-referenced-by-count': 20, 'title': 'Let fever do its job', 'prefix': '10.1093', 'volume': '9', 'author': [ { 'given': 'Sylwia', 'family': 'Wrotek', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Immunology, Nicolaus Copernicus University, Torun, ' 'Poland'}]}, { 'given': 'Edmund K', 'family': 'LeGrand', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biomedical and Diagnostic Sciences, College of ' 'Veterinary Medicine, University of Tennessee Knoxville, TN, ' 'USA'}]}, { 'given': 'Artur', 'family': 'Dzialuk', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Genetics, Kazimierz Wielki University, Bydgoszcz, ' 'Poland'}]}, { 'ORCID': 'http://orcid.org/0000-0003-0807-164X', 'authenticated-orcid': False, 'given': 'Joe', 'family': 'Alcock', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Emergency Medicine, University of New Mexico, ' 'Albuquerque, USA'}]}], 'member': '286', 'published-online': {'date-parts': [[2020, 11, 23]]}, 'reference': [ { 'key': '2021111801521653000_eoaa044-B1', 'doi-asserted-by': 'crossref', 'first-page': 'e21', 'DOI': '10.1016/S2213-2600(20)30116-8', 'article-title': 'Are patients with hypertension and diabetes mellitus at increased risk ' 'for COVID-19 infection?', 'volume': '8', 'author': 'Fang', 'year': '2020', 'journal-title': 'Lancet Respir Med'}, { 'key': '2021111801521653000_eoaa044-B2', 'doi-asserted-by': 'crossref', 'first-page': '2096', 'DOI': '10.3390/jcm9072096', 'article-title': 'ACE2 as a therapeutic target for COVID-19; its role in infectious ' 'processes and regulation by modulators of the 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