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The role of free vitamin D and vitamin D binding protein in SARS‐Cov‐2 infection in children

Us et al., Pediatrics International, doi:10.1111/ped.15680 (date from preprint), NCT05598957
Mar 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Prospective study of 82 pediatric patients in Turkey, showing symptom severity associated with free vitamin D and bioavailable vitamin D levels.
Us et al., 28 Mar 2023, prospective, Turkey, peer-reviewed, 7 authors, trial NCT05598957 (history). Contact: mcanerus@gmail.com.
This PaperVitamin DAll
The Role of Free Vitamin D and Vitamin D Binding Protein in SARS-Cov-2 Infection in Children
Mahmut Caner Us, Aslı Devrim Lanpir, Şükran Özdatlı Kurtuluş, Mesut Yağcı, Özlem Akarsu, Kamil Şahin, Gülşen Akkoç
doi:10.21203/rs.3.rs-2718581/v1
Purpose: Many studies have discussed the effects of serum vitamin D de ciency in SARS-CoV-2 patients. This study aimed to investigate the relationship between SARS-CoV-2 infection severity and free vitamin D (FVD) and bioavailable vitamin D (BAVD) levels in children. Methods: A prospective case-control study design was used. Participants were divided into three groups based on the World Health Organization (WHO) COVID-19 Clinical Progression Scale. Serum 25-hydroxyvitamin D (25OH vitamin D; ng/mL), albumin (g/L), and vitamin D binding protein (ng/mL) levels were evaluated to investigate the relationship between disease severity and FVD and BAVD levels. Results: In total, 82 participants were included in the study. Of those, 24.4 % were uninfected (n = 20), 50% had a mild case of SARSS-CoV-2 (n = 41), and 25.6% had a moderate case (n = 21). There was a statistically signi cant difference in FVD and BAVD levels between the groups (p = 0.026). Median FVD (p = 0.007, Cohen's d = 0.84) and BAVD (p = 0.007, Cohen's d = 0.86) levels were signi cantly higher in the mild group compared to the moderate group. FVD and BAVD metabolites were moderately positively correlated with lymphocyte counts (FVD: r = 0.437, p < 0.001; BAVD: r = 0.439, p < 0.001). Conclusion: This is the rst study to demonstrate a relationship between SARS-CoV-2 symptom severity and FVD and BAVD levels. The relationship between FVD and BAVD levels and lymphocyte counts could play an important role in symptom severity and should be evaluated in further studies. The study was registered with Clinical Trials (NCT05598957, 10/06/2022).
Declarations Acknowledgement: Authors thanks to all patients and their families Competing Interests: The authors have no relevant nancial or non-nancial interests to disclose. Author Contributions: All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Mahmut Caner Us, Gülşen Akkoç, Şükran Özdatli Kurtuluş, Mesut Yagci, Aslı Devrim Lanpir, Özlem Akarsu. The rst draft of the manuscript was written by Mahmut Caner Us, Gülşen Akkoç, Kamil Şahin and all authors commented on previous versions of the manuscript. All authors read and approved the nal manuscript. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the TC Health Sciences University Hamidiye Clinical Ethics Committee with protocol decision numbered 2022/10/17 and registered with Clinical Trials (NCT05598957, 10/06/2022). Consent to participate: Written informed consent was obtained from the parents. Consent to publish: participants con rmed and signed the informed consent form to the publication of the study. Congresses: This paper was presented as oral presentation at the Social Pediatric Society of Turkey's in the selected abstracts of the 3th International Eurasian Social Pediatric congress organized in İzmir (Turkey) between November 16th-20th 2022. "SS-006"
References
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This study aimed to investigate the ' 'relationship between SARS‐CoV‐2 infection severity and free vitamin D (FVD) and bioavailable ' 'vitamin D (BAVD) levels in ' 'children.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A prospective ' 'case–control study design was used. Participants were divided into three groups based on the ' 'World Health Organization COVID‐19 Clinical Progression Scale. Serum 25‐hydroxyvitamin D ' '(ng/mL), albumin (g/L), and vitamin D binding protein (ng/mL) levels were evaluated to ' 'investigate the relationship between disease severity and FVD and BAVD ' 'levels.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In total, 82 ' 'participants were included in the study. Of those, 24.4% were uninfected ' '(<jats:italic>n</jats:italic>\u2009=\u200920), 50% had a mild case of SARS‐CoV‐2 ' '(<jats:italic>n</jats:italic>\u2009=\u200941), and 25.6% had a moderate case ' '(<jats:italic>n</jats:italic>\u2009=\u200921). There was a statistically significant ' 'difference in FVD and BAVD levels between the groups (<jats:italic>p</jats:italic>\u2009' "=\u20090.026). Median FVD (<jats:italic>p</jats:italic>\u2009=\u20090.007, Cohen's " '<jats:italic>d</jats:italic>\u2009=\u20090.84) and BAVD (<jats:italic>p</jats:italic>\u2009' "=\u20090.007, Cohen's <jats:italic>d</jats:italic>\u2009=\u20090.86) levels were " 'significantly higher in the mild group compared to the moderate group. FVD and BAVD ' 'metabolites were moderately positively correlated with lymphocyte counts (FVD: ' '<jats:italic>r</jats:italic>\u2009=\u20090.437, <jats:italic>p</jats:italic>\u2009&lt;\u2009' '0.001; BAVD: <jats:italic>r</jats:italic>\u2009=\u20090.439, ' '<jats:italic>p</jats:italic>\u2009&lt;\u2009' '0.001).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This is the ' 'first study to demonstrate a relationship between SARS‐CoV‐2 symptom severity and FVD and ' 'BAVD levels. The relationship between FVD and BAVD levels and lymphocyte counts could play an ' 'important role in symptom severity and should be evaluated in further ' 'studies.</jats:p></jats:sec>', 'DOI': '10.1111/ped.15680', 'type': 'journal-article', 'created': { 'date-parts': [[2023, 10, 27]], 'date-time': '2023-10-27T11:14:22Z', 'timestamp': 1698405262000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The role of free vitamin D and vitamin D binding protein in <scp>SARS‐Cov</scp>‐2 infection in ' 'children', 'prefix': '10.1111', 'volume': '65', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-1120-3498', 'authenticated-orcid': False, 'given': 'Mahmut Caner', 'family': 'Us', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Pediatrics University of Health Sciences, Haseki ' 'Training and Research Hospital Istanbul Turkey'}, { 'name': 'Department of Social Pediatrics Marmara University, Institute of ' 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'key': 'e_1_2_11_33_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1136/bmjopen-2021-055435', 'article-title': 'Vitamin D insufficiency in COVID‐19 and influenza a, and critical ' 'illness survivors: a cross‐sectional study', 'volume': '11', 'author': 'Hurst EA', 'year': '2021', 'journal-title': 'BMJ Open'}], 'container-title': 'Pediatrics International', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/ped.15680', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 10, 27]], 'date-time': '2023-10-27T11:14:43Z', 'timestamp': 1698405283000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/ped.15680'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 1]]}, 'references-count': 32, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2023, 1]]}}, 'alternative-id': ['10.1111/ped.15680'], 'URL': 'http://dx.doi.org/10.1111/ped.15680', 'relation': {}, 'ISSN': ['1328-8067', '1442-200X'], 'subject': ['Pediatrics, Perinatology and Child Health'], 'container-title-short': 'Pediatrics International', 'published': {'date-parts': [[2023, 1]]}, 'assertion': [ { 'value': '2023-05-15', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2023-09-12', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2023-10-27', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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