Retinol Depletion in COVID-19
Aziz Rodan Sarohan, Hakan Akelma, Eşref Araç, Özgür Aslan, Osman Cen
Clinical Nutrition Open Science, doi:10.1016/j.nutos.2022.05.007
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Conflict of Interest Author contributions ARS conceived, created, and reviewed the literature, and wrote the project, protocol, and manuscript. HA selected patient and screened patient files. EA involved in official submission and follow-up of the protocol to the ethics committee. ÖA performed the statistical analysis of the data. OC reviewed literature, discussed, revised, re-organized, and re-wrote the manuscript.
Supplemental Material The Contents of the Formulas and TPN Administered to the Patients The contents of the formulas and TPN administered to the patients are given below: More than one type of TPN and formulas had been administered to some patients. 3. Omegaven® 10% 100 ml infusion emulsion. Fresenius container. 3 pcs were used in 1 individual. 100 ml contains; 10.0 g fish oil refined at high temperature: 1.25-2.82 g Eicosapentaenoic Acid (EPA), 1.44-3.09 g Docosahexaenoic acid (DHA), 0.015-0.0296 g dla-Tocopherol, 2.5 g Glycerol, 1.2 g Purified egg phospholipids, 0-0.002 g Sodium Hydroxide (pH regulator), 0.003 g Sodium oleate (emulsifier). 4. Oligoclinomel N7-1000 E electrolyte amino acid solution, glucose solution, lipid emulsion.1500 ml three-chamber bag. 7 pcs were used in 1 individual. 100 ml contains refined olive oil (80%) + Refined soya oil (20%): 4 g, essential amino acids and Sodium acetate 3EE0: 0.245 g, Sodium glycerophosphate SEEO: 0.214 g, Potassium chloride: 0.179 g, Magnesium chloride 6H2O: 0.045 g, Glucose (17.6 g glucose monohydrate):16 g,..
References
Agostino, Caranci, Negro, Piscitelli, Tuccillo et al., A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration, Journal of personalized medicine
Allegra, Tonacci, Pioggia, Musolino, Gangemi, Vitamin deficiency as risk factor for SARS-CoV-2 infection: correlation with susceptibility and prognosis, European
Arroyave, Calcaño, Decrease in serum levels of retinol and its binding protein (RBP) in infection, Archivos latinoamericanos de nutricion
Balmer, Blomhoff, Gene expression regulation by retinoic acid, Journal of lipid research
Barnabas, Brown, Bershteyn, Miller, Wener et al., Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trial, Trials
Benn, Combining vitamin A and vaccines: convenience or conflict? Danish medical, journal
Broulík, Raška, Brouliková, Prolonged overdose of all-trans retinoic acid enhances bone sensitivity in castrated mice, Nutrition
Campos, Flores, Underwood, Effect of an infection on vitamin A status of children as measured by the relative dose response (RDR). The American journal of clinical nutrition
Capone, Lucchini, Ferraro, Bianco, Rossi et al., Immunogenicity and safety of mRNA COVID-19 vaccines in people with multiple sclerosis treated with different disease-modifying therapies, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Cassani, Villablanca, Calisto, Wang, Mora, Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance, Molecular aspects of medicine
Chattha, Kandasamy, Vlasova, Saif, Vitamin A deficiency impairs adaptive B and T cell responses to a prototype monovalent attenuated human rotavirus vaccine and virulent human rotavirus challenge in a gnotobiotic piglet model, PloS one
Chung, Thone, Kwon, COVID-19 vaccines: The status and perspectives in delivery points of view. Advanced drug delivery reviews
Dhir, Dworakowski, Thangavel, Shapiro, Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone. The Journal of pharmacology and experimental therapeutics
Elias, Laurence, Davidson, Stephens, Kanno et al., Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway, Blood
Elkazzaz, Abo-Amer, Haydara, Could the candidate causal gene (LZTFL1) identified by Oxford University scientists, which doubles the risk of COVID-19-related respiratory failure
Elkazzaz, Ahmed, Shamkh, Magd, STRA6 (vitamin A receptor), as a Novel binding receptor of COVID-19, ScienceOpen Preprints
Ellinghaus, Degenhardt, Bujanda, Buti, Albillos et al., Genomewide Association Study of Severe Covid-19 with Respiratory Failure, The New England journal of medicine
Farooqi, Malik, Mulla, Hagbani, Almansour et al., An overview of SARS-COV-2 epidemiology, mutant variants, vaccines, and management strategies, Journal of infection and public health
Fortimel Energy, Ml, Nutricia, 28 pcs were used in 1 individual. 100 gram contains, Single Saturated Fat
Garbe, Buck, Hämmerling, Retinoids are important cofactors in T cell activation, The Journal of experimental medicine
Ghyselinck, Duester, Retinoic acid signaling pathways, Development
Gil, Plaza-Diaz, Mesa, Vitamin D: Classic and Novel Actions, Annals of nutrition & metabolism
Gudas, Emerging roles for retinoids in regeneration and differentiation in normal and disease states, Biochimica et biophysica acta
Huang, Liu, Qi, Brand, Zheng, Role of Vitamin A in the Immune System, Journal of clinical medicine
Huiming, Chaomin, Meng, Vitamin A for treating measles in children. The Cochrane database of systematic reviews
Iddir, Brito, Dingeo, Del Campo, Samouda et al., Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis, Nutrients
Imdad, Mayo-Wilson, Herzer, Bhutta, Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. The Cochrane database of systematic reviews
Iu, Vitamin D3 (Cholecalciferol) 220 IU, Vitamin E 11.2 IU, Vitamin C 125 mg, B Complex vitamins
Jin, Yang, Wu, Chen, Zhang, Epidemiology, Pathogenesis, and Control of COVID-19, Viruses
Krammer, SARS-CoV-2 vaccines in development, Nature
Lee, Hsieh, Ko, Molnupiravir-A Novel Oral Anti-SARS-CoV-2 Agent, Antibiotics
Lee, Ko, Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome, Scientific reports
Li, Tong, Bare, Devlin, Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults, JAMA network open
Liu, Olagnier, Lin, Host and Viral Modulation of RIG-I-Mediated Antiviral Immunity, Frontiers in immunology
Liu, Zhang, He, Hematological findings in coronavirus disease 2019: indications of progression of disease, Annals of hematology
Mahase, Covid-19: Pfizer's paxlovid is 89% effective in patients at risk of serious illness, company reports, BMJ (Clinical research ed
Mandell, A perspective on discussing COVID-19 vaccines: Efficacy and adverse effects, Cleveland Clinic journal of medicine
Mansur, Tajer, Mariani, Inserra, Ferder et al., Vitamin D high doses supplementation could represent a promising alternative to prevent or treat COVID-19 infection. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
Mcgill, Kelly, Guerra-Maupome, Winkley, Henningson et al., Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves, Scientific reports
Mehta, Fawzi, Effects of vitamins, including vitamin A, on HIV/AIDS patients, Vitamins and hormones
Meltzer, Best, Zhang, Vokes, Arora et al., Association of Vitamin D Levels, Race/Ethnicity, and Clinical Characteristics With COVID-19 Test Results, JAMA network open
Moderbacher, Ramirez, Dan, Grifoni, Hastie et al., Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity, Cell
Mohamed, Rzymski, Islam, Makuku, Mushtaq et al., COVID-19 vaccinations: The unknowns, challenges, and hopes, Journal of medical virology
Mortaz, Tabarsi, Varahram, Folkerts, Adcock, The Immune Response and Immunopathology of COVID-19, Frontiers in immunology
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial, Jama
Nakanishi, Pigazzini, Degenhardt, Cordioli, Butler-Laporte et al., genetic risk factor for COVID-19 on severity and mortality
Nelson, Buttrick, Isoherranen, Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics, Current topics in medicinal chemistry
Ni, Wei, Wu, Vitamin A for non-measles pneumonia in children. The Cochrane database of systematic reviews
Njar, Gediya, Purushottamachar, Chopra, Vasaitis et al., Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases, Bioorganic & medicinal chemistry
Novasource®, Control, Nestle. 8 pcs were used in 1 individual
Olwenyi, Dyavar, Acharya, Podany, Fletcher et al., Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19), Journal of molecular medicine
Pelkonen, Rautio, Raunio, Pasanen, CYP2A6: a human coumarin 7-hydroxylase, Toxicology
Piersma, Hessel, Staal, Retinoic acid in developmental toxicology: Teratogen, morphogen and biomarker, Reproductive toxicology
Purushottamachar, Patel, Gediya, Clement, Njar, First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): identification of novel RAMBA scaffolds, European journal of medicinal chemistry
Raverdeau, Mills, Modulation of T cell and innate immune responses by retinoic Acid, Journal of immunology
Ribero, Jouvenet, Dreux, Nisole, Interplay between SARS-CoV-2 and the type I interferon response, PLoS pathogens
Rogers, The role of cytochrome P450 in developmental pharmacology. The Journal of adolescent health : official publication of the, Society for Adolescent Medicine
Ross, Stephensen, Vitamin A and retinoids in antiviral responses, FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ross, Vitamin A and retinoic acid in T cell-related immunity, The American journal of clinical nutrition
Ross, Zolfaghari, Cytochrome P450s in the regulation of cellular retinoic acid metabolism, Annual review of nutrition
Rothan, Byrareddy, The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak, Journal of autoimmunity
Russell, The vitamin A spectrum: from deficiency to toxicity. The American journal of clinical nutrition
Samuel, Antiviral actions of interferons, Clinical microbiology reviews
Sarohan, COVID-19: Endogenous Retinoic Acid Theory and Retinoic Acid Depletion Syndrome, Medical hypotheses
Sarohan, Kızıl, İnkaya, Mahmud, Akram et al., A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder, Cellular signalling
Sarohan, Systemic Organ Involvement and Retinoid Signaling Disorder in COVID-19, Immunogenetics: Open Access
Sirisinha, The pleiotropic role of vitamin A in regulating mucosal immunity, Asian Pacific journal of allergy and immunology
Sommer, Vitamin A, infectious disease, and childhood mortality: a 2 solution? The Journal of infectious diseases
Stephensen, Lietz, Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2, The British journal of nutrition
Stephensen, Vitamin A, Infection, and Immune Function*, Annual review of nutrition
Sverko, Sobočanec, Kušić, Mačak-Šafranko, Sarić et al., Superoxide dismutase and cytochrome P450 isoenzymes might be associated with higher risk of renal cell carcinoma in male patients, International immunopharmacology
Takeuchi, Yokota-Nakatsuma, Ohoka, Kagechika, Kato et al., Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation, Journal of immunology
Tan, Liu, Zhou, Deng, Li et al., Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China, Immunology
Tanoury, Piskunov, Egly, Vitamin A and retinoid signaling: genomic and nongenomic effects, Journal of lipid research
Trasino, A role for retinoids in the treatment of COVID-19? Clinical and experimental pharmacology & physiology
Trottier, Chabot, Mann, Colombo, Chatterjee et al., Retinoids inhibit measles virus in vitro via nuclear retinoid receptor signaling pathways, Antiviral research
Usmani, Tang, Human cytochrome P450: metabolism of testosterone by CYP3A4 and inhibition by ketoconazole, Current protocols in toxicology
Van, Lee, Ortiz, Lee, Qin et al., All-trans retinoic acid inhibits type 1 diabetes by T regulatory (Treg)-dependent suppression of interferon-gamma-producing T-cells without affecting Th17 cells, Diabetes
Verfaille, Borgers, Van Steensel, Retinoic acid metabolism blocking agents (RAMBAs): a new paradigm in the treatment of hyperkeratotic disorders, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Vyas, Kurian, Bagchi, Manu, Saravu et al., Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects, Journal of the American College of Nutrition
Who, Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations
Who, WHO Coronovirus (COVID-19) Dashboard
Wiseman, Bar-El Dadon, Reifen, The vicious cycle of vitamin a deficiency: A review. Critical reviews in food science and nutrition
Wolf, Retinoic acid homeostasis: retinoic acid regulates liver retinol esterification as well as its own catabolic oxidation in liver, Nutrition reviews
Wu, Liu, Yang, Zhang, Zhong et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta pharmaceutica Sinica B
Xia, Cao, Xie, Zhang, Chen et al., Evasion of Type I Interferon by SARS-CoV-2, Cell reports
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