Retinol Depletion in COVID-19
Comparison of 27 COVID-19 ICU patients and 23 control patients, showing significantly lower vitamin A levels in COVID-19 patients.
RodanSarohan et al., 28 May 2022, retrospective, Turkey, peer-reviewed, 5 authors.
Contact:
azizrodan@gmail.com.
Abstract: Journal Pre-proof
Retinol Depletion in COVID-19
Aziz RodanSarohan, Hakan Akelma, Eşref Araç, Özgür Aslan, Osman Cen
PII:
S2667-2685(22)00029-8
DOI:
https://doi.org/10.1016/j.nutos.2022.05.007
Reference:
NUTOS 229
To appear in:
Clinical Nutrition Open Science
Received Date: 22 May 2022
Accepted Date: 23 May 2022
Please cite this article as: RodanSarohan A, Akelma H, Araç E, Aslan Ö, Cen O, Retinol Depletion in
COVID-19, Clinical Nutrition Open Science, https://doi.org/10.1016/j.nutos.2022.05.007.
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© 2022 Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.
Retinol Depletion in COVID-19
Aziz RodanSarohana*, HakanAkelmab, EşrefAraçc, ÖzgürAsland, Osman Cene,f
a. Department of Obstetrics and Gynecology, Department of Obstetric and Gynecology,
Medicina Plus Medical Center Istanbul, Turkey.
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b. Department of Anesthesiology and Reanimation. University of Health Sciences, Gazi
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Yaşargil Training and Research Hospital, Diyarbakir, Turkey.
re
Research Hospital, Diyarbakır, Turkey.
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c. Department of Internal Medicine, University of Health Sciences Gazi Yaşargil Training and
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d. Department of Medical Biochemistry, University of Health Sciences Gazi Yaşargil Training
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and Research Hospital, Diyarbakır, Turkey
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Chicago, IL
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e. Department of Microbiology, Feinberg School of Medicine, Northwestern University
f. Department of Natural Sciences and Engineering, John Wood College, Quincy, IL.
* Corresponding author: Aziz RodanSarohan
Department of Obstetrics and Gynecology, Medicina Plus Medical Center, 75. Yıl Mah., İstiklal
Cad. 1305 Sk., No: 16 Sultangazi, İstanbul, Turkey
Email: azizrodan@gmail.com
ORCID:0000-0002-5794-688X
Mobil Phone: 00905336539397
1
Abstract
Background and Aims: COVID-19 hasbeen a devastatingpandemic. There are indications that
vitamin A is depleted during infections. Vitamin A is important in development and immune
homeostasis. It has been used successfully in measles, RSV and AIDSinfections. In this study,
we aimed to measurethe serum retinol levels in severe COVID-19 patients to assessthe
importance of vitamin A in the COVID-19 pathogenesis.
of
Methods: The serum retinol level was measured in two groups of patients: the COVID-19
ro
group, which consisted of 27 severe COVID-19 patients hospitalized in the intensive care unit
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with respiratory failure, and the control group, which consisted of 23 patients without COVID-19
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symptoms.
Results: The mean serum retinol levels were 0.37 mg/L in the COVID-19 group and 0.52 mg/L
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in the control group. The difference between the serum retinol levels in the two groups was
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statistically significant.There was no significant difference in retinol levels between different
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ages and genders within the COVID-19 group. Comorbidity did not affect serum retinol levels.
Conclusion: The serum retinol level was significantly..
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