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Retinol Depletion in COVID-19

RodanSarohan et al., Clinical Nutrition Open Science, doi:10.1016/j.nutos.2022.05.007
May 2022  
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Vitamin A for COVID-19
12th treatment shown to reduce risk in January 2021
*, now known with p = 0.031 from 13 studies.
Lower risk for recovery and viral clearance.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Comparison of 27 COVID-19 ICU patients and 23 control patients, showing significantly lower vitamin A levels in COVID-19 patients.
RodanSarohan et al., 28 May 2022, retrospective, Turkey, peer-reviewed, 5 authors. Contact:
This PaperVitamin AAll
Retinol Depletion in COVID-19
Aziz Rodan Sarohan, Hakan Akelma, Eşref Araç, Özgür Aslan, Osman Cen
Clinical Nutrition Open Science, doi:10.1016/j.nutos.2022.05.007
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of Interest Author contributions ARS conceived, created, and reviewed the literature, and wrote the project, protocol, and manuscript. HA selected patient and screened patient files. EA involved in official submission and follow-up of the protocol to the ethics committee. ÖA performed the statistical analysis of the data. OC reviewed literature, discussed, revised, re-organized, and re-wrote the manuscript. Supplemental Material The Contents of the Formulas and TPN Administered to the Patients The contents of the formulas and TPN administered to the patients are given below: More than one type of TPN and formulas had been administered to some patients. 3. Omegaven® 10% 100 ml infusion emulsion. Fresenius container. 3 pcs were used in 1 individual. 100 ml contains; 10.0 g fish oil refined at high temperature: 1.25-2.82 g Eicosapentaenoic Acid (EPA), 1.44-3.09 g Docosahexaenoic acid (DHA), 0.015-0.0296 g dla-Tocopherol, 2.5 g Glycerol, 1.2 g Purified egg phospholipids, 0-0.002 g Sodium Hydroxide (pH regulator), 0.003 g Sodium oleate (emulsifier). 4. Oligoclinomel N7-1000 E electrolyte amino acid solution, glucose solution, lipid emulsion.1500 ml three-chamber bag. 7 pcs were used in 1 individual. 100 ml contains refined olive oil (80%) + Refined soya oil (20%): 4 g, essential amino acids and Sodium acetate 3EE0: 0.245 g, Sodium glycerophosphate SEEO: 0.214 g, Potassium chloride: 0.179 g, Magnesium chloride 6H2O: 0.045 g, Glucose (17.6 g glucose monohydrate):16 g,..
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