Abstract: Journal Pre-proof Retinol Depletion in COVID-19 Aziz RodanSarohan, Hakan Akelma, Eşref Araç, Özgür Aslan, Osman Cen PII: S2667-2685(22)00029-8 DOI: https://doi.org/10.1016/j.nutos.2022.05.007 Reference: NUTOS 229 To appear in: Clinical Nutrition Open Science Received Date: 22 May 2022 Accepted Date: 23 May 2022 Please cite this article as: RodanSarohan A, Akelma H, Araç E, Aslan Ö, Cen O, Retinol Depletion in COVID-19, Clinical Nutrition Open Science, https://doi.org/10.1016/j.nutos.2022.05.007. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. Retinol Depletion in COVID-19 Aziz RodanSarohana*, HakanAkelmab, EşrefAraçc, ÖzgürAsland, Osman Cene,f a. Department of Obstetrics and Gynecology, Department of Obstetric and Gynecology, Medicina Plus Medical Center Istanbul, Turkey. of b. Department of Anesthesiology and Reanimation. University of Health Sciences, Gazi ro Yaşargil Training and Research Hospital, Diyarbakir, Turkey. re Research Hospital, Diyarbakır, Turkey. -p c. Department of Internal Medicine, University of Health Sciences Gazi Yaşargil Training and lP d. Department of Medical Biochemistry, University of Health Sciences Gazi Yaşargil Training na and Research Hospital, Diyarbakır, Turkey Jo Chicago, IL ur e. Department of Microbiology, Feinberg School of Medicine, Northwestern University f. Department of Natural Sciences and Engineering, John Wood College, Quincy, IL. * Corresponding author: Aziz RodanSarohan Department of Obstetrics and Gynecology, Medicina Plus Medical Center, 75. Yıl Mah., İstiklal Cad. 1305 Sk., No: 16 Sultangazi, İstanbul, Turkey Email: azizrodan@gmail.com ORCID:0000-0002-5794-688X Mobil Phone: 00905336539397 1 Abstract Background and Aims: COVID-19 hasbeen a devastatingpandemic. There are indications that vitamin A is depleted during infections. Vitamin A is important in development and immune homeostasis. It has been used successfully in measles, RSV and AIDSinfections. In this study, we aimed to measurethe serum retinol levels in severe COVID-19 patients to assessthe importance of vitamin A in the COVID-19 pathogenesis. of Methods: The serum retinol level was measured in two groups of patients: the COVID-19 ro group, which consisted of 27 severe COVID-19 patients hospitalized in the intensive care unit -p with respiratory failure, and the control group, which consisted of 23 patients without COVID-19 lP re symptoms. Results: The mean serum retinol levels were 0.37 mg/L in the COVID-19 group and 0.52 mg/L na in the control group. The difference between the serum retinol levels in the two groups was ur statistically significant.There was no significant difference in retinol levels between different Jo ages and genders within the COVID-19 group. Comorbidity did not affect serum retinol levels. Conclusion: The serum retinol level was significantly..