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Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2 related mortality in mice

Pastor-Fernández et al., Aging Cell, doi:10.1111/acel.13771
Jan 2023  
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K18-hACE2 mouse study showing reduced COVID-19 severity with quercetin and dasatinib, for both prophylaxis and early treatment.
Pastor-Fernández et al., 26 Jan 2023, Spain, peer-reviewed, survey, 16 authors.
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Treatment with the senolytics dasatinib/quercetin reduces SARS‐CoV ‐2‐related mortality in mice
Andrés Pastor‐fernández, Antonio R Bertos, Arantzazu Sierra‐ramírez, Javier Del Moral‐salmoral, Javier Merino, Ana I De Ávila, Cristina Olagüe, Ricardo Villares, Gloria González‐aseguinolaza, María Ángeles Rodríguez, Manuel Fresno, Nuria Gironés, Matilde Bustos, Cristian Smerdou, Pablo Jose Fernandez‐marcos, Cayetano Von Kobbe
Aging Cell, doi:10.1111/acel.13771
The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the proinflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS-CoV-2 may be related to the post-COVID-19 sequelae described to date. These results place senescent cells as central targets for the treatment of COVID-19, and make D/Q a new and promising therapeutic tool.
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