Do Anti-androgens Have Potential as Therapeutics for COVID-19?

{ 'indexed': {'date-parts': [[2024, 3, 5]], 'date-time': '2024-03-05T19:30:14Z', 'timestamp': 1709667014378}, 'reference-count': 14, 'publisher': 'The Endocrine Society', 'issue': '8', 'license': [ { 'start': { 'date-parts': [[2021, 6, 5]], 'date-time': '2021-06-05T00:00:00Z', 'timestamp': 1622851200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model'}], 'funder': [ { 'DOI': '10.13039/100000002', 'name': 'National Institutes of Health', 'doi-asserted-by': 'publisher', 'award': ['DK074970', 'DK107444']}, {'name': 'American Diabetes Association COVID-19 Research Award', 'award': ['7-20-COVID-051']}, {'name': 'US Department of Veterans Affairs Merit Review Award', 'award': ['BX003725']}, {'name': 'Tulane Center of Excellence in Sex-Based Biology & Medicine'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 8, 1]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p>Coronavirus disease 2019 (COVID-19) is characterized by a gender ' 'disparity in severity, with men exhibiting higher hospitalization and mortality rates than ' 'women. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible ' 'for COVID-19, infects cells following recognition and attachment of the viral spike ' 'glycoprotein to the angiotensin-converting enzyme 2 transmembrane protein, followed by spike ' 'protein cleavage and activation by cell surface transmembrane protease serine 2 (TMPRSS2). In ' 'prostate cancer cells, androgen acting on the androgen receptor increases TMPRSS2 expression, ' 'which has led to the hypothesis that androgen-dependent expression of TMPRSS2 in the lung may ' 'increase men’s susceptibility to severe COVID-19 and that, accordingly, suppressing androgen ' 'production or action may mitigate COVID-19 severity by reducing SARS-CoV-2 amplification. ' 'Several ongoing clinical trials are testing the ability of androgen deprivation therapies or ' 'anti-androgens to mitigate COVID-19.</jats:p>\n' ' <jats:p>This perspective discusses clinical and molecular advances on the ' 'rapidly evolving field of androgen receptor (AR) action on cell surface transmembrane ' 'protease serine 2 (TMPRSS2) expression and severe acute respiratory syndrome coronavirus 2 ' '(SARS-CoV-2) infection, and the potential effect of anti-androgens on coronavirus disease ' '2019 (COVID-19) severity in male patients. It discusses limitations of current studies and ' 'offers insight for future directions.</jats:p>', 'DOI': '10.1210/endocr/bqab114', 'type': 'journal-article', 'created': {'date-parts': [[2021, 6, 5]], 'date-time': '2021-06-05T16:28:36Z', 'timestamp': 1622910516000}, 'source': 'Crossref', 'is-referenced-by-count': 11, 'title': 'Do Anti-androgens Have Potential as Therapeutics for COVID-19?', 'prefix': '10.1210', 'volume': '162', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-0874-0754', 'authenticated-orcid': False, 'given': 'Franck', 'family': 'Mauvais-Jarvis', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Medicine, Section of Endocrinology, Tulane ' 'University School of Medicine, New Orleans, LA, USA'}, { 'name': 'Tulane Center of Excellence in Sex-Based Biology & Medicine, New ' 'Orleans, LA, USA'}, {'name': 'Southeast Louisiana VA Medical Center, New Orleans, LA, USA'}]}], 'member': '80', 'published-online': {'date-parts': [[2021, 6, 5]]}, 'reference': [ { 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