Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All selenium studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchSeleniumSelenium (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

COVID-19 Severity Is Associated with Selenium Intake among Young Adults with Low Selenium and Zinc Intake in North Carolina

Larvie et al., Current Developments in Nutrition, doi:10.1016/j.cdnut.2023.100044
Feb 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Analysis of 97 COVID-19 patients in the USA, showing selenium intake inversely associated with COVID-19 severity among individuals with below median intake.
Larvie et al., 8 Feb 2023, USA, peer-reviewed, survey, 4 authors. Contact: dylarvie@uncg.edu.
This PaperSeleniumAll
COVID-19 Severity Is Associated with Selenium Intake among Young Adults with Low Selenium and Zinc Intake in North Carolina
Doreen Y Larvie, Maryanne T Perrin, George L Donati, Seth M Armah
Current Developments in Nutrition, doi:10.1016/j.cdnut.2023.100044
Background: The effects of coronavirus disease 2019 (COVID-19) remain a global public health emergency because of the ensuing economic burden and death. With robust research into vaccines, antibody treatments, and antiviral drugs for COVID-19, there is still a dearth of evidence on the role of an individual's nutritional status on the severity of COVID-19. Objective: This study aimed to investigate the association between selenium (Se) and zinc (Zn) status and COVID-19 severity among individuals diagnosed with COVID-19 in North Carolina. Methods: Subjects (n ¼ 106) were recruited remotely as part of the Nutrition and COVID-19 in North Carolina (NC-NC) study and filled out online screening questionnaires and dietary surveys. Toenail samples from 97 participants were analyzed to determine Se and Zn concentrations. To assess the severity of severe acute respiratory coronavirus (SARS-CoV)-2 infection, subjects were asked about the presence and duration of 10 commonly reported symptoms. These responses were used to calculate a COVID-19 severity index (CSI). The relationship between Se and Zn status (intake and toenail concentrations) and CSI was explored using a regression analysis. Results: Our results showed that the median (25th, 75th percentiles) dietary Se and Zn intake from selected food sources were 65.2 μg (43.2, 112.9) and 4.3 mg (1.8, 8), respectively. Headache, cough, loss of smell or taste, and fever were reported by at least half of the participants. In stepwise regression analysis, among individuals with low Se and Zn intake (below the median), Se intake was inversely associated with increasing CSI (β ¼ À0.66; 95% CI: À1.21, À0.11; P ¼ 0.02). Conclusions: Findings from this study support a potential benefit of increasing the intake of dietary Se to mitigate the severity of SARS-CoV-2 infection.
Author disclosures All authors report no conflicts of interest. Declaration of interests The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Seth Armah reports financial support was provided by North Carolina Policy Collaboratory.
References
Alimohamadi, Sepandi, Taghdir, Hosamirudsari, Determine the most common clinical symptoms in COVID-19 patients: a systematic review and meta-analysis, J. Prev. Med. Hyg
Amin, Hasan, Bhuiya, Prevalence of COVID-19 associated symptoms, their onset and duration, and variations among different groups of patients in Bangladesh, Front. Public Health
Core, None
De Araújo, Morais, De Souza Aquino, Da Silva-Maia, De Lima Vale et al., Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2, Br. J. Nutr
Demircan, Chillon, Bracken, Bulgarelli, Campi et al., Association of COVID-19 mortality with serum selenium, zinc and copper: six observational studies across Europe, Front. Immunol
Fakhrolmobasheri, Mazaheri-Tehrani, Kieliszek, Zeinalian, Abbasi et al., COVID-19 and selenium deficiency: a systematic review, Biol. Trace Elem. Res
Golabi, Adelipour, Mobarak, Piri, Seyedtabib et al., The association between vitamin D and zinc status and the progression of clinical symptoms among outpatients infected with SARS-CoV-2 and potentially non-infected participants: a cross-sectional study, Nutrients
Gordon, Hardigan, A Case-Control Study for the Effectiveness of Oral Zinc in the Prevention and Mitigation of COVID-19, Frontiers in Medicine
Gustine, Jones, Immunopathology of hyperinflammation in COVID-19, Am. J. Pathol
Guti Errez-Gonz Alez, García-Esquinas, De Larrea-Baz, Salcedo-Bellido, Navas-Acien et al., Toenails as biomarker of exposure to essential trace metals: a review, Environ. Res
Heller, Sun, Hackler, Seelig, Seibert et al., Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker, Redox Biol
Hosseini, Kashani, Nikzad, Azadbakht, Hassani et al., The novel coronavirus Disease-2019 (COVID-19): mechanism of action, detection and recent therapeutic strategies, Virology
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Im, Je, Baek, Chung, Kwon et al., Nutritional status of patients with COVID-19, Int. J. Infect. Dis
Ish, Sen, Gupta, In reference to anosmia and ageusia: common findings in COVID-19 patients, Laryngoscope
Jahromi, Moradi Tabriz, Togha, Ariyanfar, Ghorbani et al., The correlation between serum selenium, zinc, and COVID-19 severity: an observational study, BMC Infect. Dis
James, Ali, Armitage, Bonell, Cerami et al., The role of nutrition in COVID-19 susceptibility and severity of disease: a systematic review, J. Nutr
Jothimani, Kailasam, Danielraj, Nallathambi, Ramachandran et al., COVID-19: poor outcomes in patients with zinc deficiency, Int. J. Infect. Dis
Karki, Bhandari, Potential role of nutrients in immune boosting and aiding against COVID19 pathogenesis, J. Stress Physiol. Biochem
Khatiwada, Subedi, A mechanistic link between selenium and coronavirus disease 2019 (COVID-19), Curr. Nutr. Rep
Kieliszek, Lipinski, Selenium supplementation in the prevention of coronavirus infections (COVID-19), Med, Hypotheses
Kumar, Kubota, Chernov, Kasuya, Potential role of zinc supplementation in prophylaxis and treatment of COVID-19, Med, Hypotheses
Ling, Zabetakis, The role of an anti-inflammatory diet in conjunction to COVID-19, Diseases
Longnecker, Stram, Taylor, Levander, Howe et al., Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake, Epidemiology
Majumder, Minko, Recent developments on therapeutic and diagnostic approaches for COVID-19, AAPS J
Merino, Joshi, Nguyen, Leeming, Mazidi et al., Diet quality and risk and severity of COVID-19: a prospective cohort study, Gut
Moghaddam, Heller, Sun, Seelig, Cherkezov et al., Selenium deficiency is associated with mortality risk from COVID-19, Nutrients
Name, Souza, Vasconcelos, Prado, Pereira et al., and vitamin C: perspectives for COVID-19 with a focus on physical tissue barrier integrity, Front. Nutr
Ovaskainen, Virtamo, Alfthan, Haukka, Pietinen et al., Toenail selenium as an indicator of selenium intake among middle-aged men in an area with low soil selenium, Am. J. Clin. Nutr
Patridge, Bardyn, Research electronic data capture (REDCap), J. Med. Libr. Assoc
Perico, Benigni, Casiraghi, Ng, Renia et al., Immunity, endothelial injury and complement-induced coagulopathy in COVID-19, Nat. Rev. Nephrol
Satia, King, Morris, Stratton, White, Toenail and plasma levels as biomarkers of selenium exposure, Ann. Epidemiol
Sobczyk, Gaunt, The effect of circulating zinc, selenium, copper and vitamin K1 on COVID-19 outcomes: a Mendelian randomization study, Nutrients
Subramanian, Nirantharakumar, Hughes, Myles, Williams et al., Symptoms and risk factors for long COVID in nonhospitalized adults, Nat. Med
Sudre, Murray, Varsavsky, Graham, Penfold et al., Attributes and predictors of long COVID, Nat Med
Wang, Huang, Sun, Stubbs, He et al., SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis, Food Chem. Toxicol
Wessels, Rolles, Rink, The potential impact of zinc supplementation on COVID-19 pathogenesis, Front. Immunol
Who, WHO coronavirus (COVID-19) dashboard
Wiersinga, Rhodes, Cheng, Peacock, Prescott, Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review, JAMA
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir. Med
Yasui, Yasui, Suzuki, Saitou, Yamamoto et al., Analysis of the predictive factors for a critical illness of COVID-19 during treatment-relationship between serum zinc level and critical illness of COVID-19, Int. J. Infect. Dis
Zabetakis, Lordan, Norton, Tsoupras, COVID-19: the inflammation link and the role of nutrition in potential mitigation, Nutrients
Zhang, Saad, Taylor, Rayman, Selenium and selenoproteins in viral infection with potential relevance to COVID-19, Redox Biol
Zhang, Taylor, Bennett, Rayman, Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?, Gondwana Res
Zhang, Taylor, Bennett, Saad, Rayman, Association between regional selenium status and reported outcome of COVID-19 cases in China, Am. J. Clin. Nutr
{ 'indexed': {'date-parts': [[2023, 3, 9]], 'date-time': '2023-03-09T13:55:09Z', 'timestamp': 1678370109509}, 'reference-count': 47, 'publisher': 'Elsevier BV', 'issue': '3', 'license': [ { 'start': { 'date-parts': [[2023, 3, 1]], 'date-time': '2023-03-01T00:00:00Z', 'timestamp': 1677628800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2023, 2, 3]], 'date-time': '2023-02-03T00:00:00Z', 'timestamp': 1675382400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2023, 3]]}, 'DOI': '10.1016/j.cdnut.2023.100044', 'type': 'journal-article', 'created': {'date-parts': [[2023, 2, 9]], 'date-time': '2023-02-09T00:16:48Z', 'timestamp': 1675901808000}, 'page': '100044', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'COVID-19 Severity Is Associated with Selenium Intake among Young Adults with Low Selenium and ' 'Zinc Intake in North Carolina', 'prefix': '10.1016', 'volume': '7', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-3039-9385', 'authenticated-orcid': False, 'given': 'Doreen Y.', 'family': 'Larvie', 'sequence': 'first', 'affiliation': []}, {'given': 'Maryanne T.', 'family': 'Perrin', 'sequence': 'additional', 'affiliation': []}, {'given': 'George L.', 'family': 'Donati', 'sequence': 'additional', 'affiliation': []}, {'given': 'Seth M.', 'family': 'Armah', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.cdnut.2023.100044_bib3', 'doi-asserted-by': 'crossref', 'first-page': '4', 'DOI': '10.1016/j.ajpath.2020.08.009', 'article-title': 'Immunopathology of hyperinflammation in COVID-19', 'volume': '191', 'author': 'Gustine', 'year': '2021', 'journal-title': 'Am. J. Pathol.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib4', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.cdnut.2023.100044_bib5', 'doi-asserted-by': 'crossref', 'first-page': '1854', 'DOI': '10.1093/jn/nxab059', 'article-title': 'The role of nutrition in COVID-19 susceptibility and severity of ' 'disease: a systematic review', 'volume': '151', 'author': 'James', 'year': '2021', 'journal-title': 'J.\xa0Nutr.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib6', 'doi-asserted-by': 'crossref', 'first-page': '851', 'DOI': '10.1017/S0007114520003311', 'article-title': 'Nutritional status, diet and viral respiratory infections: perspectives ' 'for severe acute respiratory syndrome coronavirus 2', 'volume': '125', 'author': 'de Araújo Morais', 'year': '2021', 'journal-title': 'Br. J. Nutr.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib7', 'doi-asserted-by': 'crossref', 'first-page': '899', 'DOI': '10.1186/s12879-021-06617-3', 'article-title': 'The correlation between serum selenium, zinc, and COVID-19 severity: an ' 'observational study', 'volume': '21', 'author': 'Razeghi Jahromi', 'year': '2021', 'journal-title': 'BMC Infect. Dis.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib8', 'doi-asserted-by': 'crossref', 'first-page': '3945', 'DOI': '10.1007/s12011-021-02997-4', 'article-title': 'COVID-19 and selenium deficiency: a systematic review', 'volume': '200', 'author': 'Fakhrolmobasheri', 'year': '2022', 'journal-title': 'Biol. Trace Elem. Res.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib9', 'doi-asserted-by': 'crossref', 'first-page': '125', 'DOI': '10.1007/s13668-021-00354-4', 'article-title': 'A\xa0mechanistic link between selenium and coronavirus disease 2019 ' '(COVID-19)', 'volume': '10', 'author': 'Khatiwada', 'year': '2021', 'journal-title': 'Curr. Nutr. Rep.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib10', 'doi-asserted-by': 'crossref', 'first-page': '390', 'DOI': '10.1016/j.ijid.2020.08.018', 'article-title': 'Nutritional status of patients with COVID-19', 'volume': '100', 'author': 'Im', 'year': '2020', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib11', 'doi-asserted-by': 'crossref', 'first-page': '14', 'DOI': '10.1208/s12248-020-00532-2', 'article-title': 'Recent developments on therapeutic and diagnostic approaches for ' 'COVID-19', 'volume': '23', 'author': 'Majumder', 'year': '2021', 'journal-title': 'AAPS J'}, { 'key': '10.1016/j.cdnut.2023.100044_bib12', 'first-page': '142', 'article-title': 'Research electronic data capture (REDCap)', 'volume': '106', 'author': 'Patridge', 'year': '2018', 'journal-title': 'J.\xa0Med. Libr. Assoc.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib13', 'doi-asserted-by': 'crossref', 'first-page': '46', 'DOI': '10.1038/s41581-020-00357-4', 'article-title': 'Immunity, endothelial injury and complement-induced coagulopathy in ' 'COVID-19', 'volume': '17', 'author': 'Perico', 'year': '2021', 'journal-title': 'Nat. Rev. Nephrol.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib14', 'doi-asserted-by': 'crossref', 'first-page': 'E502', 'DOI': '10.1002/lary.28832', 'article-title': 'In reference to anosmia and ageusia: common findings in COVID-19 ' 'patients', 'volume': '130', 'author': 'Ish', 'year': '2020', 'journal-title': 'Laryngoscope'}, { 'key': '10.1016/j.cdnut.2023.100044_bib16', 'series-title': 'FoodData Central [Internet].', 'year': '2010'}, { 'key': '10.1016/j.cdnut.2023.100044_bib17', 'unstructured': 'R Core Team, Vienna, Austria; 1993. Available from: ' 'https://www.R-project.org/.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib19', 'doi-asserted-by': 'crossref', 'first-page': '420', 'DOI': '10.1016/S2213-2600(20)30076-X', 'article-title': 'Pathological findings of COVID-19 associated with acute respiratory ' 'distress syndrome', 'volume': '8', 'author': 'Xu', 'year': '2020', 'journal-title': 'Lancet Respir. Med.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib20', 'first-page': '5', 'article-title': 'Potential role of nutrients in immune boosting and aiding against ' 'COVID19 pathogenesis', 'volume': '18', 'author': 'Karki', 'year': '2022', 'journal-title': 'J.\xa0Stress Physiol. Biochem.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib21', 'doi-asserted-by': 'crossref', 'first-page': '626', 'DOI': '10.1038/s41591-021-01292-y', 'article-title': 'Attributes and predictors of long COVID', 'volume': '27', 'author': 'Sudre', 'year': '2021', 'journal-title': 'Nat Med'}, { 'key': '10.1016/j.cdnut.2023.100044_bib22', 'doi-asserted-by': 'crossref', 'first-page': '782', 'DOI': '10.1001/jama.2020.12839', 'article-title': 'Pathophysiology, transmission, diagnosis, and treatment of coronavirus ' 'disease 2019 (COVID-19): a review', 'volume': '324', 'author': 'Wiersinga', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.cdnut.2023.100044_bib23', 'first-page': 'E304', 'article-title': 'Determine the most common clinical symptoms in COVID-19 patients: a ' 'systematic review and meta-analysis', 'volume': '61', 'author': 'Alimohamadi', 'year': '2020', 'journal-title': 'J.\xa0Prev. Med. Hyg.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib24', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fpubh.2021.738352', 'article-title': 'Prevalence of COVID-19 associated symptoms, their onset and duration, ' 'and variations among different groups of patients in Bangladesh', 'volume': '9', 'author': 'Amin', 'year': '2021', 'journal-title': 'Front. Public Health'}, { 'key': '10.1016/j.cdnut.2023.100044_bib25', 'doi-asserted-by': 'crossref', 'first-page': '1706', 'DOI': '10.1038/s41591-022-01909-w', 'article-title': 'Symptoms and risk factors for long COVID in non-hospitalized adults', 'volume': '28', 'author': 'Subramanian', 'year': '2022', 'journal-title': 'Nat. Med.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib26', 'doi-asserted-by': 'crossref', 'first-page': '1466', 'DOI': '10.3390/nu12051466', 'article-title': 'COVID-19: the inflammation link and the role of nutrition in potential ' 'mitigation', 'volume': '12', 'author': 'Zabetakis', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.cdnut.2023.100044_bib27', 'doi-asserted-by': 'crossref', 'first-page': '2098', 'DOI': '10.3390/nu12072098', 'article-title': 'Selenium deficiency is associated with mortality risk from COVID-19', 'volume': '12', 'author': 'Moghaddam', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.cdnut.2023.100044_bib28', 'doi-asserted-by': 'crossref', 'first-page': '1297', 'DOI': '10.1093/ajcn/nqaa095', 'article-title': 'Association between regional selenium status and reported outcome of ' 'COVID-19 cases in China', 'volume': '111', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Am. J. Clin. Nutr.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib29', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.mehy.2020.109878', 'article-title': 'Selenium supplementation in the prevention of coronavirus infections ' '(COVID-19), Med', 'volume': '143', 'author': 'Kieliszek', 'year': '2020', 'journal-title': 'Hypotheses'}, { 'key': '10.1016/j.cdnut.2023.100044_bib30', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.redox.2020.101715', 'article-title': 'Selenium and selenoproteins in viral infection with potential relevance ' 'to COVID-19', 'volume': '37', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Redox Biol'}, { 'key': '10.1016/j.cdnut.2023.100044_bib31', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.fct.2021.112286', 'article-title': 'SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ' 'ferroptosis, endoplasmic reticulum stress and DNA synthesis', 'volume': '153', 'author': 'Wang', 'year': '2021', 'journal-title': 'Food Chem. Toxicol.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib32', 'unstructured': 'Office of Dietary Supplements, Selenium [Internet]. [cited 2018 Jan 8]. ' 'Available from: ' 'https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib33', 'doi-asserted-by': 'crossref', 'first-page': '662', 'DOI': '10.1093/ajcn/57.5.662', 'article-title': 'Toenail selenium as an indicator of selenium intake among middle-aged ' 'men in an area with low soil selenium', 'volume': '57', 'author': 'Ovaskainen', 'year': '1993', 'journal-title': 'Am. J. Clin. Nutr.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib34', 'doi-asserted-by': 'crossref', 'first-page': '384', 'DOI': '10.1097/00001648-199607000-00008', 'article-title': 'Use of selenium concentration in whole blood, serum, toenails, or urine ' 'as a surrogate measure of selenium intake', 'volume': '7', 'author': 'Longnecker', 'year': '1996', 'journal-title': 'Epidemiology'}, { 'key': '10.1016/j.cdnut.2023.100044_bib35', 'doi-asserted-by': 'crossref', 'first-page': '53', 'DOI': '10.1016/j.annepidem.2005.02.011', 'article-title': 'Toenail and plasma levels as biomarkers of selenium exposure', 'volume': '16', 'author': 'Satia', 'year': '2006', 'journal-title': 'Ann. Epidemiol.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib36', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.envres.2019.108787', 'article-title': 'Toenails as biomarker of exposure to essential trace metals: a review', 'volume': '179', 'author': 'Gutiérrez-González', 'year': '2019', 'journal-title': 'Environ. Res.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib37', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.virol.2020.08.011', 'article-title': 'The novel coronavirus Disease-2019 (COVID-19): mechanism of action, ' 'detection and recent therapeutic strategies', 'volume': '551', 'author': 'Seyed Hosseini', 'year': '2020', 'journal-title': 'Virology'}, { 'key': '10.1016/j.cdnut.2023.100044_bib38', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.mehy.2020.109848', 'article-title': 'Potential role of zinc supplementation in prophylaxis and treatment of ' 'COVID-19, Med', 'volume': '144', 'author': 'Kumar', 'year': '2020', 'journal-title': 'Hypotheses'}, { 'key': '10.1016/j.cdnut.2023.100044_bib39', 'doi-asserted-by': 'crossref', 'first-page': '1712', 'DOI': '10.3389/fimmu.2020.01712', 'article-title': 'The potential impact of zinc supplementation on COVID-19 pathogenesis', 'volume': '11', 'author': 'Wessels', 'year': '2020', 'journal-title': 'Front. Immunol.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib40', 'doi-asserted-by': 'crossref', 'first-page': '76', 'DOI': '10.3390/diseases9040076', 'article-title': 'The role of an anti-inflammatory diet in conjunction to COVID-19', 'volume': '9', 'author': 'Ling', 'year': '2021', 'journal-title': 'Diseases'}, { 'key': '10.1016/j.cdnut.2023.100044_bib41', 'doi-asserted-by': 'crossref', 'first-page': '230', 'DOI': '10.1016/j.ijid.2020.09.008', 'article-title': 'Analysis of the predictive factors for a critical illness of COVID-19 ' 'during treatment—relationship between serum zinc level and critical ' 'illness of COVID-19', 'volume': '100', 'author': 'Yasui', 'year': '2020', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib42', 'doi-asserted-by': 'crossref', 'first-page': '343', 'DOI': '10.1016/j.ijid.2020.09.014', 'article-title': 'COVID-19: poor outcomes in patients with zinc deficiency', 'volume': '100', 'author': 'Jothimani', 'year': '2020', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib43', 'doi-asserted-by': 'crossref', 'first-page': '3368', 'DOI': '10.3390/nu13103368', 'article-title': 'The association between vitamin D and zinc status and the progression ' 'of clinical symptoms among outpatients infected with SARS-CoV-2 and ' 'potentially non-infected participants: a cross-sectional study', 'volume': '13', 'author': 'Golabi', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.cdnut.2023.100044_bib51', 'doi-asserted-by': 'crossref', 'first-page': '756707', 'DOI': '10.3389/fmed.2021.756707', 'article-title': 'A Case-Control Study for the Effectiveness of Oral Zinc in the ' 'Prevention and Mitigation of COVID-19', 'volume': '8', 'author': 'Gordon', 'year': '2021', 'journal-title': 'Frontiers in Medicine'}, { 'key': '10.1016/j.cdnut.2023.100044_bib44', 'doi-asserted-by': 'crossref', 'first-page': '233', 'DOI': '10.3390/nu14020233', 'article-title': 'The effect of circulating zinc, selenium, copper and vitamin K1 on ' 'COVID-19 outcomes: a Mendelian randomization study', 'volume': '14', 'author': 'Sobczyk', 'year': '2022', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.cdnut.2023.100044_bib45', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fnut.2020.606398', 'article-title': 'Zinc, vitamin D and vitamin C: perspectives for COVID-19 with a focus ' 'on physical tissue barrier integrity', 'volume': '7', 'author': 'Name', 'year': '2020', 'journal-title': 'Front. Nutr.'}, { 'key': '10.1016/j.cdnut.2023.100044_bib46', 'article-title': 'Prediction of survival odds in COVID-19 by zinc, age and selenoprotein ' 'P as composite biomarker', 'volume': '38', 'author': 'Heller', 'year': '2020', 'journal-title': 'Redox Biol'}, { 'key': '10.1016/j.cdnut.2023.100044_bib47', 'doi-asserted-by': 'crossref', 'first-page': '2096', 'DOI': '10.1136/gutjnl-2021-325353', 'article-title': 'Diet quality and risk and severity of COVID-19: a prospective cohort ' 'study', 'volume': '70', 'author': 'Merino', 'year': '2021', 'journal-title': 'Gut'}, { 'key': '10.1016/j.cdnut.2023.100044_bib48', 'series-title': 'Dietary guidelines for Americans', 'year': '2020'}, { 'key': '10.1016/j.cdnut.2023.100044_bib49', 'doi-asserted-by': 'crossref', 'first-page': '87', 'DOI': '10.1016/j.gr.2022.05.017', 'article-title': 'Does atmospheric dimethyldiselenide play a role in reducing COVID-19 ' 'mortality?', 'volume': '114', 'author': 'Zhang', 'year': '2023', 'journal-title': 'Gondwana Res'}, { 'key': '10.1016/j.cdnut.2023.100044_bib50', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2022.1022673', 'article-title': 'Association of COVID-19 mortality with serum selenium, zinc and copper: ' 'six observational studies across Europe', 'volume': '13', 'author': 'Demircan', 'year': '2022', 'journal-title': 'Front. Immunol.'}], 'container-title': 'Current Developments in Nutrition', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2475299123005176?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S2475299123005176?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2023, 2, 28]], 'date-time': '2023-02-28T00:04:14Z', 'timestamp': 1677542654000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2475299123005176'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 3]]}, 'references-count': 47, 'journal-issue': {'issue': '3', 'published-print': {'date-parts': [[2023, 3]]}}, 'alternative-id': ['S2475299123005176'], 'URL': 'http://dx.doi.org/10.1016/j.cdnut.2023.100044', 'relation': {}, 'ISSN': ['2475-2991'], 'subject': ['Nutrition and Dietetics', 'Food Science', 'Medicine (miscellaneous)'], 'container-title-short': 'Current Developments in Nutrition', 'published': {'date-parts': [[2023, 3]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'COVID-19 Severity Is Associated with Selenium Intake among Young Adults with ' 'Low Selenium and Zinc Intake in North Carolina', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Current Developments in Nutrition', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.cdnut.2023.100044', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2023 The Authors. Published by Elsevier Inc. on behalf of American Society ' 'for Nutrition.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '100044'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit