Table 4 Number (%) of the acute COVID-19 patients with values of the studied biological variables outside the reference range Subjects with Acute patients n=75 (%) CRP values outside of the reference interval 66 (88%) Cu values outside of the reference interval less than the lower limit of the reference interval (<12.3 µmol/L) 9 (12%) higher than the upper limit of the reference interval (>24. less than the lower lower lower limit of the reference interval 1 (1.6%) higher than the upper upper limit of the reference interval 51 (79.7%) Ferritin values>500 µg/L 34 (53.1%) J o u r n a l P r e -p r o o f Authors statements The content of the paper has not been yet published or submitted for publication elsewhere. Authors also confirm that all authors have contributed significantly, and that all authors are in agreement with the content of the manuscript. Specifically, Irena Ivanova has contribute in the conceptualization, methodology, original draft, and writingreview of the revised manuscript; Ilaria Simonelli contributed in the software, data curation, statistical analyses, and visualization of the results writing of the original and revised manuscript; Amit Pal, Mauro Rongioletti and Mariacarla Ventriglia in writing -original draft, and writing -review and editing; Bisera Atanasova contributed in writing -review and editing of the revised manuscript and Rosanna Squitti contributed to the conceptualization, on writing the original draft, and writing -review and..