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The efficacy and adverse effects of favipiravir on COVID-19 patients: a systematic review and meta-analysis of published clinical trials and observational studies

Hung et al., SSRN, doi:10.2139/ssrn.3889346
Apr 2022  
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Systematic review and meta analysis of 17 favipiravir trials, showing improved viral clearance and recovery.
Currently there are 66 favipiravir studies and meta analysis shows:
OutcomeImprovement
Mortality14% lower [-1‑28%]
Ventilation8% higher [-25‑54%]
ICU admission30% higher [9‑55%]
Hospitalization4% higher [-12‑24%]
Hung et al., 22 Apr 2022, peer-reviewed, 23 authors.
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This PaperFavipiravirAll
The efficacy and adverse effects of favipiravir on patients with COVID-19: A systematic review and meta-analysis of published clinical trials and observational studies
Dang The Hung, Suhaib Ghula, Jeza Muhamad Abdul Aziz, Abdelrahman M Makram, Gehad Mohamed Tawfik, Ali Ahmed-Fouad Abozaid, Rohan Andrew Pancharatnam, Amr Mohamed Ibrahim, Muhammad Besher Shabouk, Morgan Turnage, Saloni Nakhare, Zahra Karmally, Basel Kouz, Tran Nhat Le, Suleiman Alhijazeen, Nguyen Quoc Phuong, Alaa Mohamed Ads, Ali Hussein Abdelaal, Nguyen Hai Nam, Tatsuo Iiyama, Kyoshi Kita, Kenji Hirayama, Nguyen Tien Huy
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.04.035
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Ethical Approval: This study is exempt from ethical approval. Conflict of interest We declare no competing interests.
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