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Case Cluster of RT-PCR COVID-19 Positive Patients with an Unexpected Benign Clinical Course With Vitamin D, Melatonin, Vitamin C, and Viscum Album

Hancock et al., SSRN, doi:10.2139/ssrn.3779211
Feb 2021  
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Melatonin for COVID-19
11th treatment shown to reduce risk in December 2020
*, now with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments.
Case series of 24 COVID-19 patients (12 confirmed PCR+) treated with vitamin D, vitamin C, and melatonin, showing positive outcomes with no patient having worse than a mild case, including 7 high risk patients.
Study covers melatonin, vitamin C, and vitamin D.
Hancock et al., 9 Feb 2021, preprint, 4 authors.
This PaperMelatoninAll
Case Cluster of RT-PCR COVID-19 Positive Patients with an Unexpected Benign Clinical Course With Vitamin D, Melatonin, Vitamin C, and Viscum Album
MD MPH Mark Hancock, MD Petra Ketterl, Xavier Vinas, MD Paul Werthmann
Background: The SARS-COV-2 global pandemic has been noted to have a differential effect on those exposed depending on risk factors such as age, diabetes, cardiovascular disease and cancer. Case presentation: We report a case series of 12 confirmed positive patients and 12 presumptive positive patients all of whom had either an entirely asymptomatic or relatively mild clinical course. 2 patients had active cancer, 3 patients were cancer survivors, 1 patient without cancer was 74 years old. All patients were treated early in their disease course with vitamin D loading (50,000iu daily for 3 days), 60 to 240mg melatonin, and 2000mg oral vitamin C. The 6 high risk patients and one 59 year old patient were treated with at least 2 intravenous doses of vitamin C. The 2 patients with active cancer received 75 grams of vitamin C (one daily, the other every other day). All of the high risk patients had a nearly asymptomatic clinical course and were tested after 10 days and all had a RT PCR for COVID-19 that was negative. The 17 remaining patients also had a relatively benign course though 4 patients (2 in their 20s, 2 in their 50s) received this treatment course later in the course of their illness, these were notably the only patients who had more than a mild sore throat or low grade fever. Conclusion: We report these unexpectedly positive clinical outcomes of COVID-19 patients including patients with different risk factors, under supplemental vitamin C and D and melatonin. These supplements have a favorable safety profile and are already being suggested as potentially disease altering therapies in the ongoing COVID-19 pandemic.
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Hegde, Pushpa, Maddur, Friboulet, Bayry et al., Viscum Album Exerts Anti-Inflammatory Effect by Selectively Inhibiting Cytokine-Induced Expression of Cyclooxygenase-2, PLoS ONE, doi:10.1371/journal.pone.0026312
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