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All Studies   All Outcomes    Recent:   

Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019

Dofferhoff et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa1258, ISRCTN86049077
Aug 2020  
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Retrospective 135 hospitalized COVID-19 patients showing low vitamin K status was associated with poor outcomes, elastic fiber degradation, and thrombosis risk. Dp-ucMGP, an inverse marker of extrahepatic vitamin K status, was severely elevated in COVID-19 patients compared to controls and was even higher in patients with poor outcomes (invasive ventilation and/or death). The authors propose that pneumonia-induced extrahepatic vitamin K depletion leads to impaired activation of matrix Gla protein (MGP) and endothelial protein S, resulting in accelerated elastic fiber damage and thrombosis in severe COVID-19. The study used a historical control group, limiting confidence in the results.
Dofferhoff et al., 27 Aug 2020, retrospective, Netherlands, peer-reviewed, mean age 19.0, 17 authors, trial ISRCTN86049077. Contact: jona.walk@cwz.nl.
This PaperVitamin KAll
Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19
Anton S M Dofferhoff, M.D Ianthe Piscaer, M.D Leon J Schurgers, PhD Margot P J Visser, M.D Jody M W Van Den Ouweland, Pim A De Jong, M.D Reinoud Gosens, Ph.D Tilman M Hackeng, Ph.D Henny Van Daal, Petra Lux, Cecile Maassen, Esther G A Karssemeijer, Emiel F M Wouters, Loes E M Kistemaker, Ph.D Jona Walk, M.D Rob Janssen
doi:10.1093/cid/ciaa1258/5898121
Indirectly quantified extrahepatic vitamin K status is severely reduced in COVID-19 patients. Data suggest pneumonia-induced vitamin K depletion leading to accelerated elastic fiber damage and thrombosis risk due to impaired vitamin K-dependent activation of MGP and endothelial protein S, respectively.
Authors' contributions RJ developed the theory. ASMD, RJ and LJS designed the study. LJS, PL and CM were responsible for the dp-ucMGP and PIVKA-II; and JMWO and HD for the DES measurements. PAJ performed the CT analyses. HD, EGAK, CV, MPJV and JW analyzed the data, and IP performed the statistical analysis. IP, JW and RJ wrote the first draft of the manuscript. ASMD, LJS, JMWO, PAJ, TMH, RG, LEMK, and EFMW critically revised the manuscript. Conflict of interest statements LJS reports consultancy fee from Immunodiagnostic systems and grants from NattoPharma. JMWO and RJ are owners of Desmosine.com and RJ is owner of Emphysema Solutions BV. RJ discloses application of a patent on vitamin K in COVID-19 for prognostic and therapeutic purposes. ASMD, IP, JW, MPJV, TMH, PAJ, RG, PL, HD, CM, EGAK, LEMK, CV, and EFMW declare no competing interests. Cardiac or cardiovascular disease (%) 17
References
Ackermann, Verleden, Kuehnel, Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19, N Engl J Med, doi:10.1093/cid/ciaa1258/5898121bygueston27
Basalyga, Simionescu, Xiong, Baxter, Starcher et al., Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases, Circulation
Belle, Brebant, Guinet, Leclercq, Production of a new monoclonal antibody specific to human des-gamma-carboxyprothrombin in the presence of calcium ions. Application to the development of a sensitive ELISA-test, J Immunoassay
Bhatt, Nath, Kim, Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort, Respir Res
Booth, Hadley, Cornett, Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation, Am J Respir Crit Care Med
Booth, Martini, Peterson, Saltzman, Dallal et al., Dietary phylloquinone depletion and repletion in older women, J Nutr
Bouvet, Moreau, Blanchette, De Blois, Moreau, Sequential activation of matrix metalloproteinase 9 and transforming growth factor beta in arterial elastocalcinosis, Arterioscler Thromb Vasc Biol
Brandenburg, Reinartz, Kaesler, Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study, Circulation, doi:10.1093/cid/ciaa1258/5898121bygueston27
Chatrou, Winckers, Hackeng, Reutelingsperger, Schurgers, Vascular calcification: the price to pay for anticoagulation therapy with vitamin Kantagonists, Blood Rev
Cranenburg, Koos, Schurgers, Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species, Thromb Haemost
Cranenburg, Schurgers, Uiterwijk, Vitamin K intake and status are low in hemodialysis patients, Kidney Int, doi:10.1093/cid/ciaa1258/5898121bygueston27
Cui, Chen, Li, Liu, Wang, Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia, J Thromb Haemost
Fair, Marlar, Levin, Human endothelial cells synthesize protein S, Blood
Fair, Revak, Quantitation of human protein S in the plasma of normal and warfarin-treated individuals by radioimmunoassay, Thromb Res
Fraser, Price, Lung, heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla protein. Implications for the possible functions of matrix Gla protein and for the tissue distribution of the gamma-carboxylase, J Biol Chem
Huang, Bolton, Miller, Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease, Eur Respir J
Jaminon, Dai, Qureshi, Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease, Sci Rep
Lee, Basalyga, Simionescu, Isenburg, Simionescu et al., Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses, Am J Pathol
Liao, Liu, Yuan, Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19, Nat Med
Luo, Ducy, Mckee, Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein, Nature
Nathan, Weir, Shlobin, The value of computed tomography scanning for the detection of coronary artery disease in patients with idiopathic pulmonary fibrosis, Respirology
Nigwekar, Thadhani, Brandenburg, Calciphylaxis, N Engl J Med
Ninaber, Stolk, Smit, Lung structure and function relation in systemic sclerosis: application of lung densitometry, Eur J Radiol
Noth, Anstrom, Calvert, A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis, Am J Respir Crit Care Med
Piscaer, Van Den Ouweland, Vermeersch, Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease, J Clin Med
Price, Buckley, Williamson, The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats, J Nutr
Rabinovich, Miller, Wrobel, Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD, Eur Respir J
Rucker, Calcium binding to elastin, Adv Exp Med Biol, doi:10.1093/cid/ciaa1258/5898121bygueston27
Salaffi, Carotti, Donato, Carlo, Ceccarelli et al., Computer-Aided Tomographic Analysis of Interstitial Lung Disease (ILD) in Patients with Systemic Sclerosis (SSc). Correlation with Pulmonary Physiologic Tests and Patient-Centred Measures of Perceived Dyspnea and Functional Disability, PLoS One
Schurgers, Teunissen, Hamulyak, Knapen, Vik et al., Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and nattoderived menaquinone-7, Blood
Usui, Tanimura, Nishimura, Kobayashi, Okanoue et al., Vitamin K concentrations in the plasma and liver of surgical patients, Am J Clin Nutr
Wang, Dong, Hu, Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study, Radiology
Wichmann, Sperhake, Lutgehetmann, Autopsy Findings and Venous Thromboembolism in Patients With COVID-19, Ann Intern Med
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
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