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In vivo response of the human epigenome to vitamin D: A Proof-of-principle study

Carlberg et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2018.01.002
Jan 2018  
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Epigenome-wide chromatin accessibility study before and after vitamin D supplementation (calcitriol), showing significant changes at hundreds of sites within the epigenome of human leukocytes (part of the immune system).
Carlberg et al., 6 Jan 2018, peer-reviewed, 6 authors.
This PaperVitamin DAll
In vivo response of the human epigenome to vitamin D: A Proof-of-principle study
Carsten Carlberg, Sabine Seuter, Tarja Nurmi, Tomi-Pekka Tuomainen, Jyrki K Virtanen, Antonio Neme
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2018.01.002
Highlights One individual was exposed three times every 28 days to an oral bolus (2,000 µg) of vitamin D3. At nine time points epigenome-wide chromatin accessibility was assessed by FAIRE-seq. 853 most prominent genomic loci were classified into early, delayed and non-responding A rather minor rise in 25(OH)D3 serum levels results in significant changes of the epigenome.
Adams, Singer, Gacad, Sharma, Hayes et al., Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis, J Clin Endocrinol Metabol
Aranow, Vitamin D and the immune system, FBF1 ACOX1 SUN1 Chr
Badeaux, Shi, Emerging roles for chromatin as a signal integration and storage platform, Nat Rev Mol Cell Biol
Bouillon, Carmeliet, Verlinden, Van Etten, Verstuyf et al., Vitamin D and human health: lessons from vitamin D receptor null mice, Endocr Rev
Campbell, Vitamin D and the RNA transcriptome: more than mRNA regulation, Front Physiol
Carlberg, Genome-wide (over)view on the actions of vitamin D, Front Physiol
Carlberg, Molnár, Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view, Canadian journal of physiology and pharmacology
Carlberg, The physiology of vitamin D-far more than calcium and bone, Front Physiol
Feldman, Krishnan, Swami, Giovannucci, Feldman, The role of vitamin D in reducing cancer risk and progression, Nat Rev Cancer
Garland, Gorham, Mohr, Garland, Vitamin D for cancer prevention: global perspective, Ann Epidemiol
Giovannucci, Liu, Hollis, Rimm, 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study, Arch Int Med
Giresi, Kim, Mcdaniell, Iyer, Lieb, FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin, Genome Res
Giresi, Lieb, Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements), Methods
Helin, Dhanak, Chromatin proteins and modifications as drug targets, Nature
Hewison, Freeman, Hughes, Evans, Bland et al., Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells, J Immunol
Holick, Frommer, Mcneill, Richtand, Henley et al., Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin, Biochem Biophys Res Commun
Holick, Vitamin D deficiency in 2010: health benefits of vitamin D and sunlight: a D-bate, Nat Rev Endocrinol
Holick, Vitamin D the underappreciated D-lightful hormone that is important for skeletal and cellular health, Curr Opin Endocrinol Diabetes
Hollis, Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D, J Nutr
Hossein-Nezhad, Spira, Holick, Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial, PLoS One
Hypponen, Laara, Reunanen, Jarvelin, Virtanen, Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study, Lancet
Kohonen, Self-organizing maps, Series Inform Sci
Neme, Seuter, Carlberg, Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor, Biochim Biophys Acta
Neme, Seuter, Carlberg, Vitamin D-dependent chromatin association of CTCF in human monocytes, Biochim Biophys Acta
Nurmi, Tuomainen, Virtanen, Mursu, Voutilainen, High-performance liquid chromatography and coulometric electrode array detector in serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 analyses, Anal Biochem
Pasing, Fenton, Jorde, Paulssen, Changes in the human transcriptome upon vitamin D supplementation, J Steroid Biochem Mol Biol
Ramagopalan, Heger, Berlanga, Maugeri, Lincoln et al., A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution, Genome Res
Rashid, Giresi, Ibrahim, Sun, Lieb, ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions, Genome Biol
Rosen, Adams, Bikle, Black, Demay et al., The nonskeletal effects of vitamin D: an Endocrine Society scientific statement, Endocr Rev
Seuter, Neme, Carlberg, Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF, Nucleic Acids Res
Seuter, Virtanen, Nurmi, Pihlajamäki, Mursu et al., Molecular evaluation of vitamin D responsiveness of healthy young adults, J Steroid Biochem Mol Biol
Smith, Meissner, DNA methylation: roles in mammalian development, Nat Rev Genet
Thorvaldsdottir, Robinson, Mesirov, Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration, Brief Bioinf
Verstuyf, Carmeliet, Bouillon, Mathieu, Vitamin D: a pleiotropic hormone, Kidney Int
Vukic, Neme, Seuter, Saksa, De Mello et al., Relevance of vitamin D receptor target genes for monitoring the vitamin D responsiveness of primary human cells, PLoS One
Wang, Pencina, Booth, Jacques, Ingelsson et al., Vitamin D deficiency and risk of cardiovascular disease, Circulation
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