In vivo response of the human epigenome to vitamin D: A Proof-of-principle study
Carsten Carlberg, Sabine Seuter, Tarja Nurmi, Tomi-Pekka Tuomainen, Jyrki K Virtanen, Antonio Neme
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2018.01.002
Highlights One individual was exposed three times every 28 days to an oral bolus (2,000 µg) of vitamin D3. At nine time points epigenome-wide chromatin accessibility was assessed by FAIRE-seq. 853 most prominent genomic loci were classified into early, delayed and non-responding A rather minor rise in 25(OH)D3 serum levels results in significant changes of the epigenome.
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