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Supplementary Data — Bromhexine for COVID-19: real-time meta analysis of 7 studies

Covid Analysis, June 2023
https://c19early.org/bmeta.html
 
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ansarin (RCT) 91% 0.09 [0.01-1.59] 24mg death 0/39 5/39 Improvement, RR [CI] Dose (1d) Treatment Control Ansarin (RCT) 89% 0.11 [0.01-0.84] 24mg ventilation 1/39 9/39 Ansarin (RCT) 82% 0.18 [0.04-0.77] 24mg ICU 2/39 11/39 Li (RCT) 75% 0.25 [0.05-1.35] 96mg no disch. 2/12 4/6 Li (RCT) 50% 0.50 [0.09-2.73] 96mg oxygen 2/12 2/6 Vila Méndez (RCT) 67% 0.33 [0.01-7.94] 48mg oxygen 0/98 1/93 Vila Méndez (RCT) 67% 0.33 [0.01-7.94] 48mg hosp. 0/98 1/93 Vila Méndez (RCT) 71% 0.29 [0.03-2.68] 48mg no recov. 1/52 3/45 Vila Méndez (RCT) -187% 2.87 [0.12-68.6] 48mg no recov. 1/52 0/45 Vila Méndez (RCT) -7% 1.07 [0.64-1.77] 48mg viral load 98 (n) 93 (n) Vila Méndez (RCT) 17% 0.83 [0.41-1.66] 48mg viral load 98 (n) 93 (n) Vila Méndez (RCT) -41% 1.41 [0.71-2.80] 48mg viral load 98 (n) 93 (n) Vila Méndez (RCT) 13% 0.87 [0.68-1.11] 48mg viral+ 52/98 57/93 Vila Méndez (RCT) -14% 1.14 [0.94-1.37] 48mg viral+ 73/98 61/93 Mareev (RCT) 11% 0.89 [0.65-1.22] 32mg no recov. 33 (n) 33 (n) CT​1 Mareev (RCT) 39% 0.61 [0.14-0.97] 32mg no recov. 14/24 20/21 CT​1 Mareev (RCT) 8% 0.92 [0.77-1.09] 32mg hosp. time 33 (n) 33 (n) CT​1 Mareev (RCT) 87% 0.13 [0.01-2.25] 32mg viral+ 0/17 3/13 CT​1 Tolouian (RCT) 76% 0.24 [0.01-8.03] 32mg death 48 (n) 52 (n) Tolouian (RCT) 76% 0.24 [0.01-7.69] 32mg no improv. 48 (n) 52 (n) Tolouian (RCT) -75% 1.75 [1.13-2.71] 32mg viral+ 29/48 18/52 Mikhaylov (RCT) 80% 0.20 [0.01-3.97] 24mg hosp. 0/25 2/25 Mikhaylov (RCT) 91% 0.09 [0.01-1.56] 24mg symp. case 0/25 5/25 Mikhaylov (RCT) 71% 0.29 [0.07-1.24] 24mg viral+ 2/25 7/25 Tolouian (DB RCT) 33% 0.67 [0.04-10.5] 24mg death 0/187 1/185 Tolouian (DB RCT) 70% 0.30 [0.05-1.78] 24mg hosp. 1/187 6/185 Tolouian (DB RCT) 53% 0.47 [0.25-0.87] 24mg symp. case 16/187 34/185 Tolouian (DB RCT) 50% 0.50 [0.24-0.99] 24mg cases 13/187 26/185 Bromhexine COVID-19 outcomes c19early.org/b Jun 2023 1 CT: study uses combined treatment Favors bromhexine Favors control
Figure S1. All outcomes.
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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