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All Studies   Meta Analysis    Recent:   

Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID‐19

Apaydin et al., Clinical Endocrinology, doi:10.1111/cen.14664
Dec 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Analysis of 297 hospitalized COVID-19 patients in Turkey, showing no significant association between vitamin D levels and severity, ICU admission, or mortality. VDR gene polymorphisms were independently associated with COVID-19 severity and mortality.
Apaydin et al., 25 Dec 2021, Turkey, peer-reviewed, 15 authors, study period April 2020 - October 2020. Contact: tugceapaydin88@hotmail.com, hamzapolatdr@gmail.com, dincer.ceyda@gmail.com, can.ilgin@hotmail.com, dronurelbasan@hotmail.com, drsaida90@gmail.com, bayramfeyza1@gmail.com, fetukenmez@yahoo.com, ozanunlu_57@hotmail.com, ahmetfaruk.aft@gmail.com, arslanebruuu@hotmail.com, ipekyilmaz044@gmail.com, goncahaklar@marmara.edu.tr, pinaren@gmail.com, hulyagozu@yahoo.com.
This PaperVitamin DAll
Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID‐19
MD Tugce Apaydin, MD Hamza Polat, Ceyda Dincer Yazan, MD Can Ilgin, MD Onur Elbasan, MD Saida Dashdamirova, Feyza Bayram, MD Elif Tukenmez Tigen, MD Ozan Unlu, MD Ahmet F Tekin, Ebru Arslan, Ipek Yilmaz, MD Goncagul Haklar, Pınar Ata, MD Hulya Gozu
Clinical Endocrinology, doi:10.1111/cen.14664
Purpose: Vitamin D deficiency has emerged as another potential risk factor for coronavirus disease (COVID-19) due to the immunomodulatory effects of 25 hydroxyvitamin D [25 (OH)D]. Vitamin D receptor (VDR) gene polymorphisms such as Fok I, Bsm I, Apa I, and Taq I are also associated with different courses of viral infections. This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency. Methods: Two-hundred ninety-seven patients with COVID-19 were enrolled. Serum 25 (OH)D levels were measured. Four variant regions of the VDR gene, FokI, BsmI, ApaI, and TaqI were determined.
Conflict of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Author contribution statement: All authors made substantial contributions to conception and design, and acquisition of data, and analysis and interpretation of data; participated in drafting the article or revising it critically for important intellectual content, and final approval of the version to be submitted. Ethical Approval: All procedures performed in studies involving human participants followed the institutional research committee's ethical standards, the 1964 Helsinki declaration, and its later amendments or comparable ethical standards. Informed consent: Informed consent was obtained from all participants included in the study. Abbreviations This article is protected by copyright. All rights reserved. Accepted
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This study aimed to evaluate the association between ' 'the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of ' 'COVID‐19 in respect to vitamin D ' 'deficiency.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Two‐hundred ' 'ninety‐seven patients with COVID‐19 were enrolled. Serum 25 (OH)D levels were measured. Four ' 'variant regions of the VDR gene, FokI, BsmI, ApaI, and TaqI were ' 'determined.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Eighty‐three ' 'percent of subjects had vitamin D deficiency, and 40.7% of the whole group had severe ' 'deficiency. Median 25 (OH)D level was 11.97\u2009ng/ml. Vitamin D levels were not related to ' 'inflammatory markers, disease severity, admission to intensive care unit (ICU), and ' 'mortality. While disease severity was related to Fok I Ff genotype, it was Taq TT genotype ' 'for ICU admission. Moreover, the ApaI aa genotype was common among the patients who were ' 'died. None of the deceased subjects had the Fok I FF ' 'genotype.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>25 (OH)D ' 'levels were not related to the severity and mortality of COVID‐19. 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1692972239000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/cen.14664'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 12, 25]]}, 'references-count': 46, 'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2022, 6]]}}, 'alternative-id': ['10.1111/cen.14664'], 'URL': 'http://dx.doi.org/10.1111/cen.14664', 'relation': {}, 'ISSN': ['0300-0664', '1365-2265'], 'subject': ['Endocrinology, Diabetes and Metabolism', 'Endocrinology'], 'container-title-short': 'Clinical Endocrinology', 'published': {'date-parts': [[2021, 12, 25]]}, 'assertion': [ { 'value': '2021-09-12', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2021-12-14', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2021-12-25', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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