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Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

Abdollahzadeh et al., Infection, Genetics and Evolution, doi:10.1016/j.meegid.2021.105098
Oct 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Analysis of 500 hospitalized patients in Iran, showing associations between specific vitamin D receptor gene polymorphisms and COVID-19 outcomes.
Abdollahzadeh et al., 2 Oct 2021, peer-reviewed, 9 authors.
This PaperVitamin DAll
Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients
Rasoul Abdollahzadeh, Mohammad Hossein Shushizadeh, Mina Barazandehrokh, Sepideh Choopani, Asaad Azarnezhad, Sahereh Paknahad, Maryam Pirhoushiaran, S Zahra Makani, Razieh Zarifian Yeganeh, Ahmed Al-Kateb, Roozbeh Heidarzadehpilehrood
Infection, Genetics and Evolution, doi:10.1016/j.meegid.2021.105098
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Highlights  Growing evidence indicated the critical impacts of vitamin D (VD) in prognosis of COVID-19 patients.  Significant associations were disclosed for some of the SNPs with severity, signs, symptoms, and coexisting pathologic conditions.  VDR gene polymorphisms might thus allow the prioritization of those at greater risk for COVID-19. J o u r n a l P r e -p r o o f
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