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All Studies   Meta Analysis       

Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study

Dec 2020  
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Severe case -165% Improvement Relative Risk Proton Pump Inhibitors  Zhou et al.  LATE TREATMENT Is late treatment with proton pump inhibitors beneficial for COVID-19? PSM retrospective 3,144 patients in China (January - August 2020) Higher severe cases with proton pump inhibitors (p=0.0001) c19early.org Zhou et al., Gut, December 2020 FavorsPPIs Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020, now with p = 0.00000012 from 39 studies.
5,100+ studies for 112 treatments. c19early.org
Retrospective 4,445 COVID+ patients in China, showing higher risk of combined death/intubation/ICU with famotidine and with PPIs.
Study covers famotidine and proton pump inhibitors.
risk of severe case, 165.0% higher, HR 2.65, p < 0.001, treatment 151 of 524 (28.8%), control 173 of 2,620 (6.6%), adjusted per study, death/intubation/ICU, propensity score matching, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zhou et al., 4 Dec 2020, retrospective, propensity score matching, China, peer-reviewed, 7 authors, study period 1 January, 2020 - 22 August, 2020.
This PaperPPIsAll
Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson’s disease
Pascal Derkinderen, Wendy Noble, Michel Neunlist, Malvyne Rolli-Derkinderen
Gut, doi:10.1136/gutjnl-2020-323482
PostScript Figure 1 Kaplan-Meier curve stratified by proton pump inhibitor (PPI) use before and after propensity score matching. Figure 2 Kaplan-Meier curve stratified by famotidine use before and after propensity score matching. Provenance and peer review Not commissioned; externally peer reviewed.
Competing interests None declared. Patient consent for publication Not required. ethics approval This study was approved by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster. Provenance and peer review Not commissioned; internally peer reviewed. Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise. This article is made freely available for use in accordance with BMJ's website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. Proton pump inhibitors and the risk of severe COVID-19: a post-hoc analysis from the Korean nationwide cohort We..
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Late treatment
is less effective
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