Effect of Hydroxychloroquine Use on the Length Of Hospital Stay in Children Diagnosed With Covid 19

Uygen et al., Northern Clinics of Istanbul, doi:10.14744/nci.2021.65471, Sep 2021
Time to viral- 12% improvement lower risk ← → higher risk HCQ for COVID-19  Uygen et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 40 patients in Turkey Faster viral clearance with HCQ (not stat. sig., p=0.054) c19early.org Uygen et al., Northern Clinics of Ista.., Sep 2021 0 0.5 1 1.5 2+ RR
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 424 studies, used in 59 countries.
Lower risk for mortality, hospitalization, progression, recovery, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
6,200+ studies for 200+ treatments. c19early.org
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Retrospective 40 pediatric hospitalized patients, 15 treated with HCQ, showing 7.2 vs. 8.2 days until PCR-, not quite reaching statistical significance.
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time to viral-, 12.2% lower, relative time 0.88, p = 0.05, treatment 15, control 25.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Uygen et al., 15 Sep 2021, retrospective, Turkey, peer-reviewed, 4 authors.
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org November 2025 Turkey United Kingdom Russia USA Sudan Angola Colombia Kenya Mozambique Pakistan Argentina Vietnam Peru Philippines Spain Brazil Italy France Japan China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Poland DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Bosnia-Herzegovina Ukraine Côte d'Ivoire Bulgaria Greece Slovakia Singapore Iceland New Zealand Czechia Mongolia Israel Trinidad and Tobago Hong Kong North Macedonia Belarus Qatar Panama Serbia CAR Chad Turkey favored low-cost treatments.The average efficacy of treatments was moderate.Low-cost treatments improve early treatment, andprovide complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org November 2025 Turkey United Kingdom Russia USA Sudan Angola Colombia Kenya Mozambique Pakistan Argentina Vietnam Peru Philippines Spain Brazil Italy France Japan China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Ukraine Côte d'Ivoire Eritrea Bulgaria Greece Slovakia Singapore New Zealand Czechia Mongolia Israel Trinidad and Tobago North Macedonia Belarus Qatar Panama Serbia Syria Turkey favored low-cost treatments.The average efficacy was moderate.Low-cost protocols improve early treatment,and add complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
DOI record: { "DOI": "10.14744/nci.2021.65471", "ISSN": [ "2148-4902" ], "URL": "http://dx.doi.org/10.14744/nci.2021.65471", "author": [ { "affiliation": [], "family": "Uygun", "given": "Hatice", "sequence": "first" } ], "container-title": "Northern Clinics of Istanbul", "container-title-short": "North Clin Istanbul", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2021, 9, 17 ] ], "date-time": "2021-09-17T09:19:19Z", "timestamp": 1631870359000 }, "deposited": { "date-parts": [ [ 2023, 5, 9 ] ], "date-time": "2023-05-09T18:58:09Z", "timestamp": 1683658689000 }, "indexed": { "date-parts": [ [ 2023, 5, 10 ] ], "date-time": "2023-05-10T04:26:17Z", "timestamp": 1683692777017 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2021 ] ] }, "link": [ { "URL": "https://jag.journalagent.com/nci/pdfs/NCI_8_6_562_567.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "5966", "original-title": [], "prefix": "10.14744", "published": { "date-parts": [ [ 2021 ] ] }, "published-online": { "date-parts": [ [ 2021 ] ] }, "published-print": { "date-parts": [ [ 2021 ] ] }, "publisher": "Kare Publishing", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://northclinist.com/jvi.aspx?un=NCI-65471&volume=" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "General Medicine" ], "subtitle": [], "title": "Effect of Hydroxychloroquine Use on the Length Of Hospital Stay in Children Diagnosed With Covid 19", "type": "journal-article" }
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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