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Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients

Hazan et al., Future Microbiology, doi:10.2217/fmb-2022-0014 (date from preprint), NCT04949230
Jul 2021  
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Mortality 100% Improvement Relative Risk Hospitalization 100% primary Vitamin C for COVID-19  Hazan et al.  LATE TREATMENT Is late treatment with vitamin C + combined treatments beneficial for COVID-19? Retrospective 24 patients in the USA Synthetic control arm Combined treatments may contribute more to the effect seen c19early.org Hazan et al., Future Microbiology, Jul 2021 Favorsvitamin C Favorscontrol 0 0.5 1 1.5 2+
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020, now with p = 0.000000028 from 72 studies, recognized in 12 countries.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 109 treatments. c19early.org
Small study of 24 consecutive patients in serious condition (9 days post symptoms, mean SpO2 87.4) using combined treatment with ivermectin, doxycycline, zinc, vitamin D, and vitamin C, showing no mortality or hospitalization with treatment. Two patients declined treatment and both died. This study uses a synthetic control arm.
This study is excluded in the after exclusion results of meta analysis: combined treatments may contribute more to the effect seen.
Study covers ivermectin, zinc, vitamin C, and vitamin D.
risk of death, >99.99% lower, RR < 0.001, p = 0.04, NNT 6.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, >99.99% lower, RR < 0.001, p = 0.001, NNT 3.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hazan et al., 7 Jul 2021, retrospective, USA, peer-reviewed, 7 authors, this trial uses multiple treatments in the treatment arm (combined with ivermectin, doxycycline, vitamin D, zinc) - results of individual treatments may vary, trial NCT04949230 (history).
This PaperVitamin CAll
Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients
Sabine Hazan, Sonya Dave, Anoja W Gunaratne, Sibasish Dolai, Robert L Clancy, Peter A Mccullough, Thomas J Borody
Future Microbiology, doi:10.2217/fmb-2022-0014
Ivermectin is a safe, inexpensive and effective early COVID-19 treatment validated in 20+ random, controlled trials. Having developed combination therapies for Helicobacter pylori, the authors present a highly effective COVID-19 therapeutic combination, stemming from clinical observations. Patients & methods: In 24 COVID-19 subjects refusing hospitalization with high-risk features, hypoxia and untreated moderate to severe symptoms averaging 9 days, the authors administered this novel combination of ivermectin, doxycycline, zinc and vitamins D and C. Results & conclusions: All subjects resolved symptoms (in 11 days on average), and oxygen saturation improved in 24 h (87.4% to 93.1%; p = 0.001). There were no hospitalizations or deaths, less than (p < 0.002 or 0.05, respectively) background-matched CDC database controls. Triple combination therapy is safe and effective even when used in outpatients with moderate to severe symptoms. Clinical Trial Registration: NCT04949230 (ClinicalTrial.gov)
Conclusion This study builds on extensive literature to provide practical, inexpensive, safe, readily available and highly effective IVM triple therapy aiming to prevent resistance and one that can confidently be used as a routine treatment for outpatient COVID-19. Summary points • The authors observed the effectiveness of a novel combination of ivermectin, doxycycline, zinc and vitamins D and C in 24 COVID-positive subjects with high-risk features/comorbidities. • The majority of the subjects were hypoxic (23 out of 24; oxygen saturation [SpO 2 ] <90%), with 4 below SpO 2 <85% on presentation. Many subjects had related comorbidities (n = 11; 45.8%). The median age of all subjects was 66 years old. • Intervention consisted of 10 days of doxycycline (100 mg twice a day), ivermectin (12 mg on day 1, day 4 and day 8), zinc (25 mg twice a day), vitamin D3 (1500 IU twice a day) and vitamin C (1500 mg twice a day). All treatment was given orally and ceased at the end of 10 days. • One hundred percent of patients accepting treatment survived without the need for hospitalization. All subjects recovered from hypoxic symptoms (SpO 2 >95%) within 10 days of treatment. • The authors report an effective and inexpensive COVID therapy preventing hospitalization and death in all patients and rapid resolution of hypoxia in these ambulatory 'moderately to severely' ill patients. Supplementary data To view the supplementary data that accompany this paper please visit the journal..
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Zithromax R, azithromycin tablets) and (azithromycin for oral suspension
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Late treatment
is less effective
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