Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study
et al., European Journal of Internal Medicine, doi:10.1016/j.ejim.2020.08.019, Aug 2020
HCQ for COVID-19
1st treatment shown to reduce risk in
March 2020, now with p < 0.00000000001 from 424 studies, used in 59 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
|
Retrospective 3,451 hospitalized patients, 30% reduction in mortality with HCQ after propensity adjustment, HR 0.70 [0.59 - 0.84].
|
risk of death, 30.0% lower, HR 0.70, p < 0.001, treatment 386 of 2,634 (14.7%), control 90 of 817 (11.0%), adjusted per study.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Di Castelnuovo et al., 25 Aug 2020, retrospective, Italy, peer-reviewed, 106 authors.
Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study
European Journal of Internal Medicine, doi:10.1016/j.ejim.2020.08.019
Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study The COVID-19 RISK and Treatments (CORIST) Collaboration 1 , * a r t i c l e i n f o
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.ejim.2020.08.019 .
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Late treatment
is less effective
is less effective
