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@CovidAnalysis
 

The efficacy and safety of lopinavir/ritonavir and arbidol in patients with coronavirus disease 2019

Wen et al., Zhonghua Nei Ke Za Zhi, doi:10.3760/cma.j.cn112138-20200227-00147, Aug 2020
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https://c19early.org/wen4.html
Severe case -4% Improvement Relative Risk Time to viral- -21% Lopinavir/r.. for COVID-19  Wen et al.  LATE TREATMENT Is late treatment with lopinavir/ritonavir beneficial for COVID-19? Retrospective 117 patients in China (January - February 2020) Slower viral clearance with lopinavir/ritonavir (p=0.0076) c19early.org Wen et al., Zhonghua Nei Ke Za Zhi, Aug 2020 Favorslopinavir/ritonavir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 178 hospitalized COVID-19 patients in China
Standard of Care (SOC) for COVID-19 in the study country, China, is poor with low average efficacy for approved treatments1.
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risk of severe case, 3.6% higher, RR 1.04, p = 1.00, treatment 3 of 56 (5.4%), control 3 of 58 (5.2%).
time to viral-, 20.9% higher, relative time 1.21, p = 0.008, treatment mean 10.2 (±3.49) n=59, control mean 8.44 (±3.51) n=58.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wen et al., 1 Aug 2020, retrospective, China, peer-reviewed, 11 authors, study period 20 January, 2020 - 10 February, 2020.
This PaperLopinavir/r..All
Late treatment
is less effective
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