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Factors of progression to severity and death in COVID-19 patients at two health care sites in Bamako, Mali

Traore et al., BMC Infectious Diseases, doi:10.1186/s12879-025-10456-x
Jan 2025  
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Mortality 69% Improvement Relative Risk Azithromycin  Traore et al.  LATE TREATMENT Is late treatment with azithromycin beneficial for COVID-19? Retrospective study in Mali (March 2020 - June 2022) Lower mortality with azithromycin (p=0.043) c19early.org Traore et al., BMC Infectious Diseases, Jan 2025 Favorsazithromycin Favorscontrol 0 0.5 1 1.5 2+
Retrospective 1,319 COVID-19 patients in Mali showing lower mortality with azithromycin treatment.
risk of death, 69.0% lower, HR 0.31, p = 0.04, adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Traore et al., 17 Jan 2025, retrospective, Mali, peer-reviewed, median age 43.0, 14 authors, study period 27 March, 2020 - 30 June, 2022. Contact: amtraore2008@gmail.com.
This PaperMiscellaneousAll
Factors of progression to severity and death in COVID-19 patients at two health care sites in Bamako, Mali
Abdoulaye Mamadou Traore, Mamadou Karim Toure, Mamadou Yaya Ibrahim Coulibaly, Modibo Keita, Bakary Diarra, Salif Sanafo, Garan Dabo, Mamoudou Kodio, Bourama Traore, Aminata Diarra, Adama Dicko, Hamar A Traore, Ousmane Faye, Daouda K Minta
BMC Infectious Diseases, doi:10.1186/s12879-025-10456-x
Objectives To analyze the clinical and biological characteristics and to evaluate the risk factors associated with the mortality of patients with COVID-19 in Commune IV of the District of Bamako. Methods The cohort consisted of COVID-19 patients managed from March 2020 to June 2022 at the Bamako Dermatology Hospital and the Pasteur Polyclinic in Commune IV in Bamako. The studied variables were sociodemographic, clinical, and biological. For the analysis of deaths, explanatory variables were grouped into sociodemographic factors, comorbidities and symptoms. Binomial logistic regression models were used to identify mortality associated risk factors. Results Among the 1319 included patients, 38.4% were asymptomatic, 46% and 15.5% developed moderate or severe COVID-19 respectively. The predominant signs were cough (48.5%), respiratory difficulty (24.6%) and headache (19.7%). Male were more common (58.2%). High blood pressure (19.9%) and diabetes (10%) were the main comorbidities. D-dimers < 0.5 μg/l was found in 53.3% of cases and the mean hemoglobin level was 12.9 ± 1.7 g/l. The case fatality rate was 3.71% in our series. In bivariate analysis, age > 60 years, high blood pressure, diabetes, clinical severity, D-dimers < 0.5 μg/l were associated with death. Using binomial logistic regression method, age > 60 years, increased heart rate, disease severity level and mainly acute respiratory distress syndrome (polypnea, difficulty breathing) were the factors found associated with death. After adjusting for all the assessed factors, age < 60 years [aHR = 0.15 (0.06-0.35)] and administration of azithromycin [aHR = 0.31 (0.1-0.97)] were protective factors while higher respiratory rate ] and difficulty breathing [aHR = 3.06 (1.03-9.13)] were risk factors associated with death. Conclusion These main findings elucidate the factors associated with severity and lethality external of health care system constraints. Advanced age, higher heart rate and the development of respiratory distress were the factors significantly associated with increased fatalities.
Declarations Ethics approval and consent to participate This is an observational study based on routine data. We obtained the approval of the Medical Committee of the hospital and the one of Pasteur Polyclinic. The patient or his/her legal guardian was informed that the data would be published anonymously. Consent for publication Not applicable. Competing interests The authors declare no competing interests. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
Arabi, Gordon, Derde, Nichol, Murthy et al., Lopinavir/ritonavir and hydroxychloroquine for critically ill patients with COVID-19 REMAP-CAP randomized controlled trial, Intensive Care Med
Asakura, Ogawa, COVID-19-associated coagulopathy and disseminated intravascular coagulation, Intl J Hematol
Beigel, Tomashek, Dodd, Mehta, Zingman et al., Remdesivir for the treatment of Covid-19 -preliminary report, N Engl J Med
Boulware, Pullen, Bangdiwala, Pastick, Lofgren et al., A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19, N Engl J Med
Buitrago-Garcia, Egli-Gany, Counotte, Hossmann, Imeri et al., Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: a living systematic review and meta-analysis, PLoS Med
Cai, Huang, Ou, Yu, Zhu et al., COVID-19 in a designated infectious diseases hospital outside Hubei Province, China, Allergy
Choy, Wong, Kaewpreedee, Sia, Chen et al., Remdesivir, lopinavir, ivermetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro, Antiviral Res
Cucinotta, Vanelli, WHO declares COVID-19 a pandemic, Acta Biomed
Cummings, Baldwin, Abrams, Jacobson, Meyer et al., Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study, Lancet
Devaux, Rolain, Colson, Didier, New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?, Int J Antimicrob Agents
Falagas, Mourtzoukou, Vardakas, Sex differences in the incidence and severity of respiratory tract infections, Respir Med
Flook, Jackson, Vasileiou, Simpson, Muckian et al., Informing the public health response to COVID-19: a systematic review of risk factors for disease, severity, and mortality, BMC Infect Dis
Gao, Ding, Dong, Zhang, Azkur et al., Risk factors for severe and critically ill COVID-19 patients: a review, Allergy
Gorbalenya, Baker, Baric, De Groot, Drosten et al., The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2, Nat Microbiol
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Hosmer, Lemeshow, Applied logistic regression
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Itai, Mathias, Mbuzeleni, Tafadzwa, COVID-19: Unpacking the low number of cases in Africa, Public Health Pract (Oxf ), doi:10.1016/j.puhip.2020.100038
Jaspard, Sow, Juchet, Diendere, Serra et al., Clinical presentation, outcomes and factors associated with mortality: a prospective study from three COVID-19 referral care centres in West Africa, Int J Infect Dis
Liang, Guan, Chen, Li, Xu, Cancer patients in SARSCoV-2 infection: a nationwide analysis in China, Lancet Oncol
Muller, Bulubas, Vogel, Les facteurs pronostiques dans la COVID-19, Npg Gériatrie
Pijls, Jolani, Atherley, Derckx, Dijkstra et al., Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies, BMJ Open
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area, JAMA
Rothman, Greenland, Lash, Modern epidemiology
Shaw, Joshi, Greenwood, Panda, Lord, Aging of the innate immune system, Curr Opin Immunol
Wan, Li, Ye, Yang, Cai et al., CT manifestations and clinical characteristics of 1115 patients with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis, Acad Radiol
Wan, Xiang, Fang, Zheng, Li et al., Clinical features and treatment of COVID-19 patients in northeast Chongqing, J Med Virol
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA
Wang, Li, Chen, Yan, Li et al., Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China, Am J Nephrol
Wen, Chen, Tang, Wang, Zhou et al., Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and paxlovid) for COVID-19: a meta-analysis, Ann Med
Yang, Shen, Hou, Is ivermectin effective in treating COVID-19?, Front Pharmacol
Yang, Yu, Xu, Shu, Xia et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneuminia in Wuhan China: a single-centered, retrospective, observational study, Lancet Respir Med
Zhang, Dong, Liu, Gao, Risk and protective factors for COVID-19 morbidity, severity, and mortality, Clin Rev Allergy Immunol
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID19 in Wuhan, China: a retrospective cohort study, Lancet
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Late treatment
is less effective
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