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Darunavir/Cobicistat Is Associated with Negative Outcomes in HIV-Negative Patients with Severe COVID-19 Pneumonia

Milic et al., AIDS Research and Human Retroviruses, doi:10.1089/AID.2020.0305, Apr 2021
https://c19early.org/milic.html
Mortality -150% Improvement Relative Risk Death/intubation -48% Darunavir for COVID-19  Milic et al.  LATE TREATMENT Is late treatment with darunavir beneficial for COVID-19? Retrospective 273 patients in Italy Higher mortality (p=0.0001) and death/intubation (p=0.03) c19early.org Milic et al., AIDS Research and Human .., Apr 2021 Favorsdarunavir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 273 hospitalized COVID-19 patients showing higher mortality with darunavir/cobicistat treatment.
risk of death, 149.5% higher, RR 2.50, p < 0.001, treatment 115, control 158.
risk of death/intubation, 47.8% higher, RR 1.48, p = 0.03, treatment 115, control 158.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Milic et al., 1 Apr 2021, retrospective, Italy, peer-reviewed, 25 authors.
DOI record: { "DOI": "10.1089/aid.2020.0305", "ISSN": [ "0889-2229", "1931-8405" ], "URL": "http://dx.doi.org/10.1089/AID.2020.0305", "alternative-id": [ "10.1089/aid.2020.0305" ], "author": [ { "affiliation": [ { "name": "Department of Surgical, Medical, Dental, and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy." }, { "name": "Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy." } ], "family": "Milic", "given": "Jovana", "sequence": "first" }, { "affiliation": [ { "name": "Pharmacotherapy and Appropriateness of Drug Prescription Unit, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy." } ], "family": "Novella", "given": "Alessio", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Meschiari", "given": "Marianna", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Menozzi", "given": "Marianna", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Santoro", "given": "Antonella", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Bedini", "given": "Andrea", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Cuomo", "given": "Gianluca", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Franceschini", "given": "Erica", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Digaetano", "given": "Margherita", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Carli", "given": "Federica", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Ciusa", "given": "Giacomo", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Volpi", "given": "Sara", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Bacca", "given": "Erica", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Franceschi", "given": "Giacomo", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Yaacoub", "given": "Dina", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Rogati", "given": "Carlotta", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Tutone", "given": "Marco", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Burastero", "given": "Giulia", "sequence": "additional" }, { "affiliation": [ { "name": "Infectious Diseases Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy." } ], "family": "Faltoni", "given": "Matteo", 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Late treatment
is less effective
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