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All Studies   Meta Analysis    Recent:   

Effectiveness of a multidrug therapy consisting of ivermectin, azithromycin, montelukast and acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico

Lima-Morales et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.02.014
Feb 2021  
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Mortality 78% Improvement Relative Risk Ventilation 52% Hospitalization 67% Recovery 59% Montelukast  Lima-Morales et al.  LATE TREATMENT Is late treatment with montelukast + combined treatments beneficial for COVID-19? Prospective study of 768 patients in Mexico Lower mortality (p=0.001) and hospitalization (p=0.001) c19early.org Lima-Morales et al., Int. J. Infectiou.., Feb 2021 Favorsmontelukast Favorscontrol 0 0.5 1 1.5 2+
28th treatment shown to reduce risk in November 2021
 
*, now with p = 0.0045 from 8 studies.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Prospective trial of 768 COVID-19 outpatients in Mexico, 481 treated with ivermectin, AZ, montelukast, and aspirin, and 287 control patients with various treatments, showing significantly lower mortality and hospitalization, and significantly higher recovery at 14 days with treatment.
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Study covers ivermectin, montelukast, and aspirin.
risk of death, 77.7% lower, RR 0.22, p < 0.001, treatment 15 of 481 (3.1%), control 52 of 287 (18.1%), NNT 6.7, adjusted per study, odds ratio converted to relative risk, multivariate.
risk of mechanical ventilation, 51.9% lower, RR 0.48, p = 0.15, treatment 8 of 434 (1.8%), control 11 of 287 (3.8%), NNT 50.
risk of hospitalization, 67.4% lower, RR 0.33, p < 0.001, treatment 44 of 481 (9.1%), control 89 of 287 (31.0%), NNT 4.6, adjusted per study, odds ratio converted to relative risk, multivariate.
risk of no recovery, 58.6% lower, RR 0.41, p < 0.001, treatment 75 of 481 (15.6%), control 118 of 287 (41.1%), NNT 3.9, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, recovery at day 14 after symptoms, multivariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lima-Morales et al., 10 Feb 2021, prospective, Mexico, peer-reviewed, 10 authors, average treatment delay 7.2 days, this trial uses multiple treatments in the treatment arm (combined with azithromycin, montelukast, and aspirin) - results of individual treatments may vary.
This PaperMontelukastAll
Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico
René Lima-Morales, Pablo Méndez-Hernández, Yvonne N Flores, Patricia Osorno-Romero, Christian Ronal Sancho-Hernández, Elizabeth Cuecuecha-Rugerio, Adrián Nava-Zamora, Diego Rolando Hernández-Galdamez, Daniela Karola Romo-Dueñas, Jorge Salmerón
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.02.014
There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid ("TNR4" therapy) to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. Design and methods: A comparative effectiveness study was performed among 768 confirmed SARS-CoV-2 cases aged 18-80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment. Results: Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group. Conclusions: TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases.
Differences between means were estimated from linear regression, and differences between proportions were evaluated using the chi2 test. A p-value 0.05 was considered to be significant. Proportions and means were adjusted by age, sex, comorbidities, and occupation. A p-value 0Á05 was considered significant. a Comparison group: participants who did not accept the TNR4 treatment because they were asymptomatic, were already taking another treatment, or they had self-medicated for cold and flu. However, they agreed to take part in the follow-up portion of the study. Conflict of interest The authors declare no conflict of interest in this article. Ethical approval Approval for this study was granted by the Ministry of Health of the Tlaxcala state, Mexico (#CEI02092020).
References
Almerie, Kerrigan, The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast, Med Hypotheses
Anderson, Meredith, Yeung, Frei, Selwyn et al., The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion, N Engl J Med
Arshad, Kilgore, Chaudhry, Jacobsen, Wang et al., Treatment with Hydroxychloroquine, Azithromycin, and combination in patients hospitalized with COVID-19, Int J Infect Dis
Awortwe, Cascorbi, Meta-analysis on outcome-worsening comorbidities of COVID-19 and related potential drug-drug interactions, Pharmacol Res
Back, Marzolini, Hodge, Marra, Boyle et al., COVID-19 treatment in patients with comorbidities: Awareness of drug-drug interactions, Br J Clin Pharmacol
Baud, Qi, Nielsen-Saines, Musso, Pomar et al., Real estimates of mortality following COVID-19 infection, Lancet Infect Dis
Beigel, Tomashek, Dodd, Mehta, Zingman et al., Remdesivir for the treatment of Covid-19-Preliminary report, N Engl J Med
Bianconi, Violi, Fallarino, Pignatelli, Sahebkar et al., Is acetylsalicylic acid a safe and potentially useful choice for adult patients with cOVID-19?, Drugs
Bleyzac, Goutelle, Bourguignon, Tod, Azithromycin for COVID-19: More than just an antimicrobial?, Clin Drug Investig
Bozek, Winterstein, Montelukast's ability to fight COVID-19 infection, J Asthma
Cai, Yang, Liu, Chen, Shu et al., Experimental treatment with favipiravir for COVID-19: An open-label control study
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Res
Cao, Wang, Wen, Liu, Wang et al., A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19, N Engl J Med
Carvallo, Hirsch, Farinella, Safety and efficacy of the combined use of Ivermectin, dexamethasone, enoxaparin and aspirin against COVID-19, medRxiv
Cavalcanti, Zampieri, Rosa, Azevedo, Veiga et al., Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19, doi:10.1056/NEJMoa2019014
Damle, Vourvahis, Wang, Leaney, Corrigan, Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID-19, Clin Pharmacol Ther
David, Frank, Rémy, Oliver, Anti-tumor necrosis factor-α treatment improves endothelial function in patients with rheumatoid arthritis, Circulation
El-Aziz, Stockand, Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) -An update on the status, Infect Genet Evol
Fang, Karakiulakis, Roth, Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?, Lancet Resp Med
Feldmann, Maini, Woody, Holgate, Winter et al., Trials of anti-tumor necrosis factor therapy for COVID-19 are urgently needed, Lancet
Fidan, Aydo, As a potential treatment of COVID-19: Montelukast, Med Hypotheses
Flammer, Sudano, Hermann, Gay, Forster et al., Angiotensinconverting enzyme inhibition improves vascular function in rheumatoid arthritis, Circulation, doi:10.1161/CIRCULATIONAHA.107.734384
Gao, Tian, Yang, Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies, Biosci Trends
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Gupta, Sahoo, Singh, Ivermectin: Potential candidate for the treatment of Covid 19, Braz J Infect Dis
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Hung, Lung, Tso, Liu, Chung et al., Triple combination of interferon beta-1b, lopinavir-2013; ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: An open-label, randomised, phase 2 trial, Lancet, doi:10.1016/S0140-6736(20)31042-4
Jabeen, Khader, Jabeen, A review on the antiparasitic drug ivermectin for various viral infections and possibilities of using it for novel Severe Acute Respiratory Syndrome Coronavirus 2: New hope to treat coronavirus disease
Janiaud, Axfors, Van't Hooft, Saccilotto, Agarwal et al., The worldwide clinical trial research response to the COVID-19 pandemic -The first 100 days
Jean, Lee, Hsueh, Treatment options for COVID-19: The reality and challenges, J Microbiol Immunol Infect
Li, Hao, Zhao, Du, Zhou, SARS-CoV-2 infection-induced immune responses: Friends or foes?, Scand J Immunol
Ortega, Zambrano, Jastrzebska, Liprandi, Rangel et al., Understanding severe acute respiratory syndrome coronavirus 2 replication to design efficient drug combination therapies, Intervirology
Pani, Lauriola, Romandini, Scaglione, Macrolides and viral infections: Focus on Azithromycin in COVID-19 pathology, Int J Antimicrob Agents
Poduri, Joshi, Jagadeesh, Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19, Cell Signal
Portmann-Baracco, Alberti, Accinelli, Antiviral and anti-inflammatory of Ivermectin and its potential use in COVID-19, Arch Bronchomeunol, doi:10.1016/j.arbres.2020.06.011
Rajter, Sherman, Fatteh, Vogel, Sacks et al., ICON (Ivermectin in COvid Nineteen) study: Use of Ivermectin is associated with lower mortality in hospitalized patients with COVID19, medRxiv
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with Hydroxychloroquine or Azithromycin with inhospital mortality in patients with COVID-19 in New York State, JAMA
Sanders, Monogue, Jodlowski, Cutrell, Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A review, JAMA
Taddei, Virdis, Ghiadoni, Mattei, Salvetti, Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients, J Hypertens
Tang, Li, Wang, Sun, Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia, J Thromb Haemost
Tsang, Chan, Cho, Yu, Yim et al., An update on COVID-19 pandemic: The epidemiology, pathogenesis, prevention and treatment strategies, Expert Rev Anti Infect Ther
Varga, Flammer, Steiger, Haberecker, Andermatt et al., Endothelial cell infection and endotheliitis in COVID-19, Lancet
Viecca, Radovanovic, Forleo, Santus, Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study, Pharmacol Res
Wang, Zhang, Du, Du, Zhao et al., Remdesivir in adults with severe COVID-19: A randomised, double-blind, placebo-controlled, multicentre trial, Lancet
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'10.1080/02770903.2020.1786112', 'article-title': 'Montelukast’s ability to fight COVID-19 infection', 'author': 'Bozek', 'year': '2020', 'journal-title': 'J Asthma'}, { 'issue': 'March', 'key': '10.1016/j.ijid.2021.02.014_bib0060', 'first-page': '1', 'article-title': 'Experimental treatment with favipiravir for COVID-19: An open-label ' 'control study', 'author': 'Cai', 'year': '2020', 'journal-title': 'Engineering (Beijing, China)'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0065', 'doi-asserted-by': 'crossref', 'first-page': '104787', 'DOI': '10.1016/j.antiviral.2020.104787', 'article-title': 'The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 ' 'in vitro', 'volume': '178', 'author': 'Caly', 'year': '2020', 'journal-title': 'Antiviral Res'}, { 'issue': '19', 'key': '10.1016/j.ijid.2021.02.014_bib0070', 'doi-asserted-by': 'crossref', 'first-page': '1787', 'DOI': '10.1056/NEJMoa2001282', 'article-title': 'A trial of lopinavir-ritonavir in adults hospitalized with 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risk ' 'for COVID-19 infection?', 'volume': '8', 'author': 'Fang', 'year': '2020', 'journal-title': 'Lancet Resp Med'}, { 'issue': 'May (10234)', 'key': '10.1016/j.ijid.2021.02.014_bib0105', 'doi-asserted-by': 'crossref', 'first-page': '1407', 'DOI': '10.1016/S0140-6736(20)30858-8', 'article-title': 'Trials of anti-tumor necrosis factor therapy for COVID-19 are urgently ' 'needed', 'volume': '395', 'author': 'Feldmann', 'year': '2020', 'journal-title': 'Lancet (London, England)'}, { 'issue': 'May', 'key': '10.1016/j.ijid.2021.02.014_bib0110', 'doi-asserted-by': 'crossref', 'first-page': '109828', 'DOI': '10.1016/j.mehy.2020.109828', 'article-title': 'As a potential treatment of COVID-19: Montelukast', 'volume': '142', 'author': 'Fidan', 'year': '2020', 'journal-title': 'Med Hypotheses'}, { 'issue': '17', 'key': '10.1016/j.ijid.2021.02.014_bib0115', 'doi-asserted-by': 'crossref', 'first-page': '2262', 'DOI': '10.1161/CIRCULATIONAHA.107.734384', 'article-title': 'Angiotensin-converting enzyme inhibition improves vascular function in ' 'rheumatoid arthritis', 'volume': '117', 'author': 'Flammer', 'year': '2008', 'journal-title': 'Circulation'}, { 'issue': 'March (1)', 'key': '10.1016/j.ijid.2021.02.014_bib0120', 'doi-asserted-by': 'crossref', 'first-page': '72', 'DOI': '10.5582/bst.2020.01047', 'article-title': 'Breakthrough: Chloroquine phosphate has shown apparent efficacy in ' 'treatment of COVID-19 associated pneumonia in clinical studies', 'volume': '14', 'author': 'Gao', 'year': '2020', 'journal-title': 'Biosci Trends'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0125', 'series-title': 'Datos Abiertos de México — Información Referente a Casos COVID-19 en ' 'México – Bases de Datos COVID-19', 'first-page': '1', 'author': 'Gobierno de México', 'year': '2020'}, { 'issue': 'February (18)', 'key': '10.1016/j.ijid.2021.02.014_bib0130', 'doi-asserted-by': 'crossref', 'first-page': '1708', 'DOI': '10.1056/NEJMoa2002032', 'article-title': 'Clinical characteristics of coronavirus disease 2019 in China', 'volume': '382', 'author': 'Guan', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0135', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.bjid.2020.06.002', 'article-title': 'Ivermectin: Potential candidate for the treatment of Covid 19', 'author': 'Gupta', 'year': '2020', 'journal-title': 'Braz J Infect Dis'}, { 'issue': 'February (10223)', 'key': '10.1016/j.ijid.2021.02.014_bib0140', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'issue': 'May (10238)', 'key': '10.1016/j.ijid.2021.02.014_bib0145', 'doi-asserted-by': 'crossref', 'first-page': '1695', 'DOI': '10.1016/S0140-6736(20)31042-4', 'article-title': 'Triple combination of interferon beta-1b, lopinavir–2013; ritonavir, ' 'and ribavirin in the treatment of patients admitted to hospital with ' 'COVID-19: An open-label, randomised, phase 2 trial', 'volume': '395', 'author': 'Hung', 'year': '2020', 'journal-title': 'Lancet'}, { 'issue': 'June', 'key': '10.1016/j.ijid.2021.02.014_bib0150', 'doi-asserted-by': 'crossref', 'first-page': '21', 'DOI': '10.22159/ajpcr.2020.v13i8.38357', 'article-title': 'A review on the antiparasitic drug ivermectin for various viral ' 'infections and possibilities of using it for novel Severe Acute ' 'Respiratory Syndrome Coronavirus 2: New hope to treat coronavirus ' 'disease-2019', 'volume': '13', 'author': 'Jabeen', 'year': '2020', 'journal-title': 'Asian J Pharm Clin Res'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0155', 'doi-asserted-by': 'crossref', 'first-page': '1193', 'DOI': '10.12688/f1000research.26707.1', 'article-title': 'The worldwide clinical trial research response to the COVID-19 pandemic ' '— The first 100 days', 'volume': '9', 'author': 'Janiaud', 'year': '2020', 'journal-title': 'F1000Research'}, { 'issue': 'June (3)', 'key': '10.1016/j.ijid.2021.02.014_bib0160', 'doi-asserted-by': 'crossref', 'first-page': '436', 'DOI': '10.1016/j.jmii.2020.03.034', 'article-title': 'Treatment options for COVID-19: The reality and challenges', 'volume': '53', 'author': 'Jean', 'year': '2020', 'journal-title': 'J Microbiol Immunol Infect'}, { 'issue': 'August (2)', 'key': '10.1016/j.ijid.2021.02.014_bib0165', 'article-title': 'SARS-CoV-2 infection-induced immune responses: Friends or foes?', 'volume': '92', 'author': 'Li', 'year': '2020', 'journal-title': 'Scand J Immunol'}, { 'issue': 'October', 'key': '10.1016/j.ijid.2021.02.014_bib0170', 'first-page': '1', 'article-title': 'Understanding severe acute respiratory syndrome coronavirus 2 ' 'replication to design efficient drug combination therapies', 'author': 'Ortega', 'year': '2020', 'journal-title': 'Intervirology'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0175', 'doi-asserted-by': 'crossref', 'first-page': '106053', 'DOI': '10.1016/j.ijantimicag.2020.106053', 'article-title': 'Macrolides and viral infections: Focus on Azithromycin in COVID-19 ' 'pathology', 'volume': '56', 'author': 'Pani', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents'}, { 'issue': 'October', 'key': '10.1016/j.ijid.2021.02.014_bib0180', 'doi-asserted-by': 'crossref', 'first-page': '109721', 'DOI': '10.1016/j.cellsig.2020.109721', 'article-title': 'Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring ' 'promising drugs for the treatment of Covid-19', 'volume': '74', 'author': 'Poduri', 'year': '2020', 'journal-title': 'Cell Signal'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0185', 'article-title': 'Antiviral and anti-inflammatory of Ivermectin and its potential use in ' 'COVID-19', 'author': 'Portmann-Baracco', 'year': '2020', 'journal-title': 'Arch Bronchomeunol'}, { 'issue': 'January', 'key': '10.1016/j.ijid.2021.02.014_bib0190', 'article-title': 'ICON (Ivermectin in COvid Nineteen) study: Use of Ivermectin is ' 'associated with lower mortality in hospitalized patients with COVID19', 'author': 'Rajter', 'year': '2020', 'journal-title': 'medRxiv'}, { 'issue': 'June (24)', 'key': '10.1016/j.ijid.2021.02.014_bib0195', 'doi-asserted-by': 'crossref', 'first-page': '2493', 'DOI': '10.1001/jama.2020.8630', 'article-title': 'Association of treatment with Hydroxychloroquine or Azithromycin with ' 'in-hospital mortality in patients with COVID-19 in New York State', 'volume': '323', 'author': 'Rosenberg', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': 'April', 'key': '10.1016/j.ijid.2021.02.014_bib0200', 'article-title': 'Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A ' 'review', 'author': 'Sanders', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0205', 'series-title': 'NORMA Oficial Mexicana NOM-017-SSA2-2012', 'author': 'Secretaría de Salud', 'year': '2013'}, { 'key': '10.1016/j.ijid.2021.02.014_bib0210', 'series-title': 'Lineamiento Estandarizado para la Vigilancia Epidemiológica y por ' 'Laboratorio de la Enfermedad Respiratoria Viral', 'author': 'Secretaría de Salud-Gobierno de México', 'year': '2020'}, { 'issue': 'April (4)', 'key': '10.1016/j.ijid.2021.02.014_bib0215', 'doi-asserted-by': 'crossref', 'first-page': '447', 'DOI': '10.1097/00004872-199816040-00006', 'article-title': 'Effects of angiotensin converting enzyme inhibition on ' 'endothelium-dependent vasodilatation in essential hypertensive patients', 'volume': '16', 'author': 'Taddei', 'year': '1998', 'journal-title': 'J Hypertens'}, { 'issue': 'April (4)', 'key': '10.1016/j.ijid.2021.02.014_bib0220', 'doi-asserted-by': 'crossref', 'first-page': '844', 'DOI': '10.1111/jth.14768', 'article-title': 'Abnormal coagulation parameters are associated with poor prognosis in ' 'patients with novel coronavirus pneumonia', 'volume': '18', 'author': 'Tang', 'year': '2020', 'journal-title': 'J 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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