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One-year mortality and associated factors in older hospitalized COVID-19 survivors: a Nationwide Cohort Study in Korea

Kim et al., Scientific Reports, doi:10.1038/s41598-024-76871-3
Oct 2024  
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Mortality 53% Improvement Relative Risk Macrolides for COVID-19  Kim et al.  LATE TREATMENT Is late treatment with macrolides beneficial for COVID-19? Retrospective 63,369 patients in South Korea (Oct 2020 - Dec 2021) Lower mortality with macrolides (p<0.000001) c19early.org Kim et al., Scientific Reports, October 2024 Favorsmacrolides Favorscontrol 0 0.5 1 1.5 2+
Retrospective 63,369 hospitalized COVID-19 survivors aged 60 years or older in Korea, showing lower 1-year mortality with macrolides (including azithromycin), higher 1-year mortality with corticosteroids (including dexamethasone and methylprednisolone), and no significant difference with HCQ (only used for 0.2% of patients).
risk of death, 53.0% lower, OR 0.47, p < 0.001, treatment 1,837, control 61,532, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kim et al., 22 Oct 2024, retrospective, South Korea, peer-reviewed, 7 authors, study period 8 October, 2020 - 31 December, 2021. Contact: wido21@cau.ac.kr.
This PaperMiscellaneousAll
One-year mortality and associated factors in older hospitalized COVID-19 survivors: a Nationwide Cohort Study in Korea
Eunji Kim, Jeong-Yeon Kim, Kyoung Min Moon, Tae Wan Kim, Won-Young Kim, Sun‑young Jung, Moon Seong Baek
Scientific Reports, doi:10.1038/s41598-024-76871-3
This study aimed to evaluate the 1-year mortality rate among older patients with COVID-19 discharged from hospital and to identify risk factors associated with this outcome. Using a COVID-19 dataset from the Korean National Health Insurance System, this study's evaluation period spanned from October 8, 2020, through December 31, 2021. The primary outcome was the 1-year mortality rate following hospital discharge. A logistic regression model was employed for multivariable analysis to estimate the odds ratios for the outcomes, and the Kaplan-Meier method was used to analyze differences in 1-year survival rates. Among the 66,810 COVID-19 patients aged 60 years or older who were hospitalized during the study period, the in-hospital mortality rate was 4.8% (n = 3219). Among the survivors (n = 63,369), the 1-year mortality rate was 4.9% (n = 3093). Non-survivors, compared to survivors, were significantly older (79.2 ± 9.5 vs. 68.9 ± 7.8, P < 0.001) and exhibited a lower rate of COVID-19 vaccination (63.0% vs. 91.7%, P < 0.001). Additionally, non-survivors experienced a higher incidence of organ dysfunction, along with a greater proportion of required mechanical ventilation (14.6% vs. 1.0%, P < 0.001) and extracorporeal membrane oxygenation (4.0% vs. 0.1%, P < 0.001). Multivariable logistic regression analysis identified older age, male sex, cardiovascular disease, immunosuppression, organ dysfunction, illness severity, and corticosteroid use during hospitalization as factors associated with death within 1 year after hospital discharge. However, vaccination was found to have a long-term protective effect against death among COVID-19 survivors. The 1-year mortality rate after hospital discharge for older COVID-19 patients was comparable to the in-hospital mortality rate for these patients in Korea. The long-term mortality rate among hospitalized older COVID-19 patients was influenced by demographic factors and the severity of illness experienced during hospitalization.
Author contributions MSB and SYJ conceived and designed the study. EK, JYK, SYJ, and MSB collected the primary data and conducted data analyses. EK, KMM, TWK, WYK, SYJ, and MSB interpreted the results and prepared the first draft. All the authors revised the draft for important intellectual content and approved the final manuscript submitted for publication. Declarations Competing interests The authors declare no competing interests. Ethics approval and consent to participate The study protocol was approved by the Institutional Review Board of Chung-Ang University (1041078-20221111-BR-010). Informed consent was waived because data analyses were performed retrospectively using anonymized data from the South Korean NHIS database. All procedures in this study were performed according to the relevant guidelines and regulations. Consent for publication Not applicable. Additional information Supplementary Information The online version contains supplementary material available at https://doi. org/10.1038/s41598-024-76871-3 .
References
Adjaye-Gbewonyo, Vahratian, Perrine, Bertolli, Long COVID in adults: United States, NCHS Data Brief
Agarwal, Ziaeian, Lavie, Fonarow, Cardiovascular disease in hospitalized patients with a diagnosis of coronavirus from the pre-COVID-19 era in United States: national analysis from 2016-2017, Mayo Clin. Proc, doi:10.1016/j.mayocp.2020.09.022
Baek, Lee, Kim, Choi, Jung, COVID-19-related outcomes in immunocompromised patients: a nationwide study in Korea, PLoS One, doi:10.1371/journal.pone.0257641
Baptista, Vieira, Capela, Julião, Macedo, COVID-19 fatality rates in hospitalized patients: a new systematic review and meta-analysis, J. Infect. Public. Health, doi:10.1016/j.jiph.2023.07.006
Bowles, Surviving COVID-19 after Hospital discharge: symptom, functional, and adverse outcomes of home health recipients, Ann. Intern. Med, doi:10.7326/m20-5206
Buonsenso, Piazza, Boner, Bellanti, Long, A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome, Allergy Asthma Proc, doi:10.2500/aap.2022.43.220018
Cañas, Racial and ethnic disparities post-hospitalization for COVID-19: barriers to access to care for survivors of COVID-19 acute respiratory distress syndrome, Sci. Rep, doi:10.1038/s41598-024-61097-0
Chen, Survival benefit of a third dose of the COVID-19 vaccine among hemodialysis patients: a prospective cohort study, J. Microbiol. Immunol. Infect, doi:10.1016/j.jmii.2023.09.002
Cho, Song, Oh, Quality of life and long-term mortality among survivors of extracorporeal membrane oxygenation: a Nationwide Cohort Study in South Korea, Crit. Care Med, doi:10.1097/ccm.0000000000005015
Choi, Song, Oh, Quality of life and mortality among survivors of acute respiratory distress syndrome in South Korea: a nationwide cohort study, J. Anesth, doi:10.1007/s00540-022-03036-9
Davis, Mccorkell, Vogel, Topol, Long, Major findings, mechanisms and recommendations, Nat. Rev. Microbiol, doi:10.1038/s41579-022-00846-2
Di Bari, COVID-19, vulnerability, and long-term mortality in hospitalized and nonhospitalized older persons, J. Am. Med. Dir. Assoc, doi:10.1016/j.jamda.2021.12.009
Dodd, Endpoints for randomized controlled clinical trials for COVID-19 treatments, Clin. Trials, doi:10.1177/1740774520939938
Fernández-De-Las-Peñas, Differences in Long-COVID symptoms between Vaccinated and non-vaccinated (BNT162b2 vaccine) hospitalized COVID-19 survivors infected with the delta variant, Vaccines, doi:10.3390/vaccines10091481
Graña, Efficacy and safety of COVID-19 vaccines, Cochrane Database Syst. Rev
Guillon, Laurent, Godillon, Kimmoun, Grammatico-Guillon, Long-term mortality of elderly patients after intensive care unit admission for COVID-19, Intensive Care Med, doi:10.1007/s00134-021-06399-x
Günster, 6-month mortality and readmissions of hospitalized COVID-19 patients: a nationwide cohort study of 8,679 patients in Germany, PLoS One, doi:10.1371/journal.pone.0255427
Han, Jang, Oh, Excess mortality during the coronavirus disease pandemic in Korea, BMC Public. Health, doi:10.1186/s12889-023-16546-2
Holbig, Navigating the dual dilemma between lives, rights and livelihoods: COVID-19 responses in China, Singapore, and South Korea, Z. für Vergleichende Politikwissenschaft, doi:10.1007/s12286-023-00555-x
Horby, Dexamethasone in hospitalized patients with Covid-19, N Engl. J. Med, doi:10.1056/NEJMoa2021436
Huang, Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study, Lancet Respir. Med, doi:10.1016/s2213-2600(22)00126-6
Hägglöf, Bell, Zettersten, Engerström, Larsson, Long-term survival after intensive care for COVID-19: a nationwide cohort study of more than 8000 patients, Ann. Intensive Care, doi:10.1186/s13613-023-01156-3
Iwashyna, Late mortality after COVID-19 infection among US veterans vs risk-matched comparators: a 2-year cohort analysis, JAMA Intern. Med, doi:10.1001/jamainternmed.2023.3587
Kamdar, Joblessness and lost earnings after acute respiratory distress syndrome in a 1-year national multicenter study, Am. J. Respir Crit. Care Med, doi:10.1164/rccm.201611-2327OC
Lam, Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection, Nat. Commun, doi:10.1038/s41467-024-45953-1
Merdji, Sex and gender differences in intensive care medicine, Intensive Care Med, doi:10.1007/s00134-023-07194-6
Mizrahi, Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study, Bmj, doi:10.1136/bmj-2022-072529
Munblit, Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19, Clin. Exp. Allergy, doi:10.1111/cea.13997
Munch, Effect of 12 mg vs 6 mg of Dexamethasone on the number of days alive without life support in adults with COVID-19 and severe hypoxemia: the COVID STEROID 2 Randomized Trial, Jama, doi:10.1001/jama.2021.18295
Nyberg, Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis, Bmj, doi:10.1136/bmj.n1412
Pazukhina, Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID), BMC Med, doi:10.1186/s12916-022-02448-4
Pourhoseingholi, Predicting 1-year post-COVID-19 mortality based on chest computed tomography scan, J. Med. Virol, doi:10.1002/jmv.27146
Ramzi, Hospital readmissions and post-discharge all-cause mortality in COVID-19 recovered patients; a systematic review and meta-analysis, Am. J. Emerg. Med, doi:10.1016/j.ajem.2021.10.059
Santos, Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: a prospective cohort study, PLoS One, doi:10.1371/journal.pone.0293883
Thygesen, COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records, Lancet Digit. Health, doi:10.1016/s2589-7500(22)00091-7
Tsampasian, Risk factors Associated with Post-COVID-19 Condition: a systematic review and Meta-analysis, JAMA Intern. Med, doi:10.1001/jamainternmed.2023.0750
Uusküla, Long-term mortality following SARS-CoV-2 infection: a national cohort study from Estonia, Lancet Reg. Health Eur, doi:10.1016/j.lanepe.2022.100394
Yan, Death toll of COVID-19 on Asian americans: disparities revealed, J. Gen. Intern. Med, doi:10.1007/s11606-021-07003-0
Zettersten, Long-term outcome after intensive care for COVID-19: differences between men and women-a nationwide cohort study, Crit. Care, doi:10.1186/s13054-021-03511-x
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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