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@CovidAnalysis
 

Association between ramelteon and 30-day mortality in ICU patients with COVID-19: A retrospective analysis of the MIMIC-IV database

Tian et al., British Journal of Clinical Pharmacology, doi:10.1002/bcp.70099, May 2025
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https://c19early.org/tian3.html
Mortality 47% ramelteon Improvement Relative Risk Melatonin for COVID-19  Tian et al.  ICU PATIENTS Is very late treatment with melatonin beneficial for COVID-19? PSM retrospective 1,066 patients in China Lower mortality with melatonin (p=0.0053) c19early.org Tian et al., British J. Clinical Pharm.., May 2025 Favorsmelatonin Favorscontrol 0 0.5 1 1.5 2+
Melatonin for COVID-19
11th treatment shown to reduce risk in December 2020, now with p = 0.000000047 from 19 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,700+ studies for 161 treatments. c19early.org
PSM retrospective 1,066 ICU patients in China, showing significantly lower mortality with ramelteon treatment.
Standard of Care (SOC) for COVID-19 in the study country, China, is poor with low average efficacy for approved treatments1.
Important missing comments or errors? Let us know.
risk of death, 47.0% lower, HR 0.53, p = 0.005, treatment 301, control 301, adjusted per study, propensity score matching, multivariable, ramelteon.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tian et al., 19 May 2025, retrospective, China, peer-reviewed, 3 authors.
This PaperMelatoninAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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