All Studies Meta Analysis

Mouth Rinses for Inactivation of COVID-19 (MOR)

Jacox et al., NCT04584684, MOR, NCT04584684

Oct 2021

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Hydrogen Peroxide

21st treatment shown to reduce risk in May 2021, now with p = 0.029 from 7 studies.

Lower risk for viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

129 patient hydrogen peroxide early treatment RCT with results not reported over 3 years after completion.

4 hydrogen peroxide RCTs have results missing long after expected1-4
The trials report a total of 323 patients, with 2 trials having actual enrollment of 183, and the remainder estimated.

Important missing comments or errors? Let us know.

Study covers chlorhexidine, cetylpyridinium chloride, povidone-iodine, and hydrogen peroxide.

1. Gansky et al., Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (AMPoL), NCT04409873, clinicaltrials.gov/study/NCT04409873.clinicaltrials.gov.

2. Khan et al., A quadruple blind, randomised controlled trial of gargling agents in reducing intraoral viral load among hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial, Trials, doi:10.1186/s13063-020-04634-2.biomedcentral.com, doi.org.

3. Xie et al., Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection, NCT04931004, clinicaltrials.gov/study/NCT04931004.clinicaltrials.gov.

4. Jacox et al., Mouth Rinses for Inactivation of COVID-19 (MOR), NCT04584684, clinicaltrials.gov/study/NCT04584684.clinicaltrials.gov.

Jacox et al., 20 Oct 2021, Double Blind Randomized Controlled Trial, USA, trial NCT04584684 (history) (MOR). Contact: ljacox@live.unc.edu.

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