Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection

Xie et al., NCT04931004, NCT04931004, Feb 2022

Source

PDF

All
Studies

Meta
Analysis

Hydrogen Peroxide

22nd treatment shown to reduce risk in May 2021, now with p = 0.029 from 7 studies.

Lower risk for viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,500+ studies for 121 treatments. c19early.org

Estimated 90 patient hydrogen peroxide early treatment RCT with results not reported over 3 years after estimated completion.

4 hydrogen peroxide RCTs have results missing long after expected1-4
The trials report a total of 323 patients, with 2 trials having actual enrollment of 183, and the remainder estimated.

Important missing comments or errors? Let us know.

Study covers chlorhexidine, cetylpyridinium chloride, and hydrogen peroxide.

1. Gansky et al., Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (AMPoL), NCT04409873, clinicaltrials.gov/study/NCT04409873.clinicaltrials.gov.

2. Khan et al., A quadruple blind, randomised controlled trial of gargling agents in reducing intraoral viral load among hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial, Trials, doi:10.1186/s13063-020-04634-2.biomedcentral.com, doi.org.

3. Xie et al., Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection, NCT04931004, clinicaltrials.gov/study/NCT04931004.clinicaltrials.gov.

4. Jacox et al., Mouth Rinses for Inactivation of COVID-19 (MOR), NCT04584684, clinicaltrials.gov/study/NCT04584684.clinicaltrials.gov.

Xie et al., 28 Feb 2022, Double Blind Randomized Controlled Trial, placebo-controlled, trial NCT04931004 (history).

This Paper Hydrogen Per..All

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0