Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection

Xie et al., NCT04931004, NCT04931004, Feb 2022

Hydrogen Peroxide for COVID-19

23rd treatment shown to reduce risk in May 2021, now with p = 0.024 from 8 studies.
Lower risk for viral clearance.

No treatment is 100% effective.
Protocols combine treatments.

Estimated 90 patient hydrogen peroxide early treatment RCT with results not reported over 4 years after estimated completion.
2 hydrogen peroxide RCTs have results missing long after expected1,2
The trials report an estimated total of 140 patients.
Study covers chlorhexidine, cetylpyridinium chloride, and hydrogen peroxide.
Xie et al., 28 Feb 2022, Double Blind Randomized Controlled Trial, placebo-controlled, trial NCT04931004 (history).