All Studies Meta Analysis

Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection

Xie et al., NCT04931004, NCT04931004

Feb 2022

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Hydrogen Peroxide

21st treatment shown to reduce risk in May 2021, now with p = 0.029 from 7 studies.

Lower risk for viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

Estimated 90 patient hydrogen peroxide early treatment RCT with results not reported over 2 years after estimated completion.

4 hydrogen peroxide RCTs have results missing long after expected1-4
The trials report a total of 323 patients, with 2 trials having actual enrollment of 183, and the remainder estimated.

Important missing comments or errors? Let us know.

Study covers chlorhexidine, cetylpyridinium chloride, and hydrogen peroxide.

1. Gansky et al., Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (AMPoL), NCT04409873, clinicaltrials.gov/study/NCT04409873.clinicaltrials.gov.

2. Khan et al., A quadruple blind, randomised controlled trial of gargling agents in reducing intraoral viral load among hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial, Trials, doi:10.1186/s13063-020-04634-2.biomedcentral.com, doi.org.

3. Xie et al., Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection, NCT04931004, clinicaltrials.gov/study/NCT04931004.clinicaltrials.gov.

4. Jacox et al., Mouth Rinses for Inactivation of COVID-19 (MOR), NCT04584684, clinicaltrials.gov/study/NCT04584684.clinicaltrials.gov.

Xie et al., 28 Feb 2022, Double Blind Randomized Controlled Trial, placebo-controlled, trial NCT04931004 (history).

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