Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection

Xie et al., NCT04931004, NCT04931004

Feb 2022

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Estimated 90 patient cetylpyridinium chloride early treatment RCT with results not reported over 2 years after estimated completion.

5 cetylpyridinium chloride RCTs have results missing long after expected1-5
The trials report a total of 528 patients, with 3 trials having actual enrollment of 288, and the remainder estimated.

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Study covers chlorhexidine, cetylpyridinium chloride, and hydrogen peroxide.

1. Jacox et al., Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2), NCT05178173, clinicaltrials.gov/study/NCT05178173.clinicaltrials.gov.

2. Gansky et al., Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (AMPoL), NCT04409873, clinicaltrials.gov/study/NCT04409873.clinicaltrials.gov.

3. Xie et al., Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection, NCT04931004, clinicaltrials.gov/study/NCT04931004.clinicaltrials.gov.

4. Correa et al., Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes, NCT04902976, clinicaltrials.gov/study/NCT04902976.clinicaltrials.gov.

5. Jacox (B) et al., Mouth Rinses for Inactivation of COVID-19 (MOR), NCT04584684, clinicaltrials.gov/study/NCT04584684.clinicaltrials.gov.

Xie et al., 28 Feb 2022, Double Blind Randomized Controlled Trial, placebo-controlled, trial NCT04931004 (history).

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