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Curcumin reduces COVID-19 risk: real-time meta analysis of 27 studies

Covid Analysis, May 2025
https://c19early.org/catmeta.html
Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021, now with p = 0.0000000096 from 27 studies.
No treatment is 100% effective. Protocols combine treatments.
5,700+ studies for 135 treatments. c19early.org
Significantly lower risk is seen for mortality, ventilation, hospitalization, progression, recovery, and viral clearance. 18 studies from 16 independent teams in 8 countries show significant benefit.
Meta analysis using the most serious outcome reported shows 41% [30‑51%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies.
Results are very robust — in exclusion sensitivity analysis 26 of 27 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
Control Curcumin
Studies typically use advanced formulations for greatly improved bioavailability.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Dietary sources may be preferred. The quality of non-prescription supplements varies widely1-3. All data and sources to reproduce this analysis are in the appendix.
4 other meta analyses show significant improvements with curcumin for mortality4-7, hospitalization4,7, recovery6, and symptoms4.
4 meta analyses show significant improvements with curcumin for mortality1-4, hospitalization1,4, recovery3, and symptoms1.
Covid Analysis et al., May 2025, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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