Curcumin reduces COVID-19 risk: real-time meta analysis of 28 studies

Covid Analysis, Dec 2025
Curcumin for COVID-19
16th treatment shown to reduce risk in February 2021, now with p = 0.0000000061 from 28 studies.
No treatment is 100% effective. Protocols combine treatments.
6,300+ studies for 210+ treatments. c19early.org
Significantly lower risk is seen for mortality, ventilation, hospitalization, progression, recovery, and viral clearance. 19 studies from 17 independent teams in 9 countries show significant benefit.
Meta analysis using the most serious outcome reported shows 41% [30‑50%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies.
Results are very robust — in exclusion sensitivity analysis 27 of 28 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
Control Curcumin
Studies typically use advanced formulations for greatly improved bioavailability.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Dietary sources may be preferred. The quality of non-prescription supplements varies widely1-3. All data and sources to reproduce this analysis are in the appendix.
6 other meta analyses show significant improvements with curcumin for mortality4-9, mechanical ventilation9, hospitalization4,7, recovery6,9, progression9, and symptoms4.
6 meta analyses show significant improvements with curcumin for mortality1-6, mechanical ventilation6, hospitalization1,4, recovery3,6, progression6, and symptoms1.
Covid Analysis et al., Dec 2025, preprint, 1 author.
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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