Curcumin reduces COVID-19 risk: real-time meta analysis of 28 studies
, Dec 2025
Curcumin for COVID-19
16th treatment shown to reduce risk in
February 2021, now with p = 0.0000000061 from 28 studies.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
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Significantly lower risk is seen for mortality, ventilation, hospitalization, progression, recovery, and viral clearance. 19 studies from 17 independent teams in 9 countries show significant benefit.
Meta analysis using the most serious outcome reported shows 41% [30‑50%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies.
Results are very robust — in exclusion sensitivity analysis 27 of 28 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
Control Curcumin
Studies typically use advanced formulations for greatly improved bioavailability.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Dietary sources may be preferred. The quality of non-prescription supplements varies widely1-3. All data and sources to reproduce this analysis are in the appendix.
6 other meta analyses show significant improvements with curcumin for mortality4-9, mechanical ventilation9, hospitalization4,7, recovery6,9, progression9, and symptoms4.
6 meta analyses show significant improvements with curcumin for mortality1-6,
mechanical ventilation6,
hospitalization1,4,
recovery3,6,
progression6, and
symptoms1.
1.
Vahedian-Azimi et al., Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials, Nutrients, doi:10.3390/nu14020256.
2.
Kow et al., The effect of curcumin on the risk of mortality in patients with COVID-19: A systematic review and meta-analysis of randomized trials, Phytotherapy Research, doi:10.1002/ptr.7468.
3.
Shafiee et al., Curcumin for the treatment of COVID-19 patients: A meta-analysis of randomized controlled trials, Phytotherapy Research, doi:10.1002/ptr.7724.
4.
Shojaei et al., The effectiveness of nano‐curcumin on patients with COVID‐19: A systematic review of clinical trials, Phytotherapy Research, doi:10.1002/ptr.7778.
Covid Analysis et al., Dec 2025, preprint, 1 author.
