Statistically significant lower risk is seen for mortality, ventilation, ICU admission, progression, and viral clearance. 14 studies from 12 independent teams in 2 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 31% [16‑42%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies.
Results are robust — in exclusion sensitivity analysis 8 of 18 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective.
All data to reproduce this paper and sources are in the appendix. Other meta analyses show significant improvements with azvudine for mortality1,2, mechanical ventilation1, clinical improvement1, and viral clearance1.
2 meta analyses show significant improvements with azvudine for mortality
Wang,
Zheng,
mechanical ventilation
Zheng,
improvement
Zheng, and
viral clearance
Zheng.
Covid Analysis et al., May 2024, preprint, 1 author.