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Impact of steam inhalation, saline gargling, and povidone-iodine gargling on clinical outcome of COVID-19 patients in Bengaluru, Karnataka: A randomized control trial

Chalageri et al., Indian Journal of Community Medicine, doi:10.4103/ijcm.ijcm_804_21
Jul 2022  
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Hospitalization -200% Improvement Relative Risk Recovery 43% NaCl  Chalageri et al.  EARLY TREATMENT  RCT Is early treatment with NaCl beneficial for COVID-19? RCT 40 patients in India (September 2020 - February 2021) Improved recovery with NaCl (p=0.0004) c19early.org Chalageri et al., Indian J. Community .., Jul 2022 FavorsNaCl Favorscontrol 0 0.5 1 1.5 2+
RCT with 20 saline and 20 control low risk patients in India, showing faster recovery with saline gargling, but no significant difference in viral clearance.
risk of hospitalization, 200.0% higher, RR 3.00, p = 1.00, treatment 1 of 20 (5.0%), control 0 of 20 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of no recovery, 42.9% lower, RR 0.57, p < 0.001, treatment median 4.0 IQR 3.5 n=17, control median 7.0 IQR 2.8 n=20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chalageri et al., 11 Jul 2022, Randomized Controlled Trial, India, peer-reviewed, mean age 38.6, 15 authors, study period September 2020 - February 2021. Contact: ssdrsaras@gmail.com.
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