• Statistically significant improvements are seen for mortality, hospitalization, cases, and viral clearance. 10 studies from 10 independent teams in 8 different countries show statistically significant improvements in isolation (7 for the most serious outcome).• Meta analysis using the most serious outcome reported shows 51% [37‑61%] improvement. Results are similar for Randomized Controlled Trials, similar after exclusions, and similar for peer-reviewed studies. Early treatment is more effective than late treatment. • Results are robust — in exclusion sensitivity analysis 16 of 20 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.• Some studies only test short term viral load after a single application. Excessive use of PVP-I could affect thyroid function. • No treatment, vaccine, or intervention is 100% effective and available. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. Only 15% of povidone-iodine studies show zero events with treatment. • All data to reproduce this paper and sources are in the appendix. Other meta analyses for povidone-iodine can be found in [Hasan, Idrees], showing significant improvements for viral clearance and viral load.