Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study

DOI record: { "DOI": "10.1097/cce.0000000000000305", "ISSN": [ "2639-8028" ], "URL": "http://dx.doi.org/10.1097/CCE.0000000000000305", "abstract": "<jats:p>We conducted a multicenter cohort study to determine the effect of drug therapies on survival in mechanically ventilated patients with coronavirus disease 2019. All consecutive adult patients admitted to ICU for coronavirus disease 2019 from March 1, 2020, to April 25, 2020, and under invasive mechanical ventilation for more than 24 hours were included. Out of 2,003 patients hospitalized for coronavirus disease 2019, 361 were admitted to ICU, 257 were ventilated for more than 24 hours, and 247 were included in the study. Simple and multiple time-dependent Cox regression models were used to assess the effects of factors on survival. Methylprednisolone administration during the first week of mechanical ventilation was associated with a decrease in mortality rate from 48% to 34% (<jats:italic toggle=\"yes\">p</jats:italic> = 0.01). Mortality was significantly associated with older age, higher creatinine, lower lymphocyte count, and mean arterial pressure lower than 70 mm Hg on the day of admission.</jats:p>", "author": [ { "affiliation": [ { "name": "Department of Intensive Care, University Hospital of Liege, Liege, Belgium" } ], "family": "Lambermont", "given": "Bernard", "sequence": "first" }, { "affiliation": [ { "name": "Biostatistics and Medico-economic information Department, University Hospital of Liege, Liege, Belgium" } ], "family": "Ernst", "given": "Marie", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, Centre Hospitalier Chrétien (CHC) MontLegia, Liege, Belgium" } ], "family": "Demaret", "given": "Pierre", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, Centre Hospitalier Régional (CHR) de Liege, Liege, Belgium" } ], "family": "Boccar", "given": "Sandrine", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, CHR East Belgium, Verviers, Belgium" } ], "family": "Gurdebeke", "given": "Christine", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, Clinique Notre-Dame de Grâce, Gosselies, Belgium" } ], "family": "Cedric", "given": "Van Brussel", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, Centre Hospitalier du Bois de l’Abbaye, Seraing, Belgium" } ], "family": "Quinonez", "given": "Manuel", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, CHC Hermalle, Liege, Belgium" } ], "family": "Dubois", "given": "Christophe J. J.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, Centre Hospitalier (CH) André Renard, Herstal, Belgium" } ], "family": "Lemineur", "given": "Thierry", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, CH Malmedy, Malmedy, Belgium" } ], "family": "Njambou", "given": "Thierry", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, Klinik St Josef VoG, St Vith, Belgium" } ], "family": "Akando", "given": "Benoit", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, CHR, Huy, Belgium" } ], "family": "Wertz", "given": "Damien", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, University Hospital of Namur (Université Catholique de Louvain), Dinant, Belgium" } ], "family": "Higny", "given": "Julien", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Nephrology, University Hospital of Liege, Liege, Belgium" } ], "family": "Delanaye", "given": "Pierre", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care, University Hospital of Liege, Liege, Belgium" } ], "family": "Misset", "given": "Benoit", "sequence": "additional" } ], "container-title": "Critical Care Explorations", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2020, 11, 25 ] ], "date-time": "2020-11-25T20:01:49Z", "timestamp": 1606334509000 }, "deposited": { "date-parts": [ [ 2023, 10, 21 ] ], "date-time": "2023-10-21T00:04:49Z", "timestamp": 1697846689000 }, "indexed": { "date-parts": [ [ 2023, 10, 21 ] ], "date-time": "2023-10-21T12:15:53Z", "timestamp": 1697890553697 }, "is-referenced-by-count": 3, "issue": "12", "issued": { "date-parts": [ [ 2020, 11, 25 ] ] }, "journal-issue": { "issue": "12", "published-online": { "date-parts": [ [ 2020 ] ] } }, "language": "en", "license": [ { "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "content-version": "unspecified", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 11, 25 ] ], "date-time": "2020-11-25T00:00:00Z", "timestamp": 1606262400000 } } ], "link": [ { "URL": "https://journals.lww.com/10.1097/CCE.0000000000000305", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "276", "original-title": [], "page": "e0305", "prefix": "10.1097", "published": { "date-parts": [ [ 2020, 11, 25 ] ] }, "published-online": { "date-parts": [ [ 2020, 11, 25 ] ] }, "publisher": "Ovid Technologies (Wolters Kluwer Health)", "reference": [ { "DOI": "10.1093/cid/ciaa601", "article-title": "Early short course corticosteroids in hospitalized patients with COVID-19.", "author": "Fadel", "doi-asserted-by": "crossref", "journal-title": "Clin Infect Dis", "key": "R1-20231020", "year": "2020 May 19" }, { "article-title": "Dexamethasone in hospitalized patients with 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"source": "Crossref", "subject": [ "Critical Care and Intensive Care Medicine" ], "subtitle": [], "title": "Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study", "type": "journal-article", "volume": "2" }