Usefulness of Topical Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR)
et al., NCT04425850, NCT04425850, Oct 2020
Ivermectin for COVID-19
4th treatment shown to reduce risk in
August 2020, now with p < 0.00000000001 from 106 studies, recognized in 24 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,200+ studies for
200+ treatments. c19early.org
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Prophylaxis study using ivermectin and carrageenan showing 0 of 131 cases from treated healthcare workers, compared to 11 of 98 control.
The effect is likely to be primarily due to ivermectin - the author has later reported that carrageenan is not necessary1.
See2 for discussion of issues with this trial.
Targeted administration to the respiratory tract provides treatment directly
to the typical source of initial SARS-CoV-2 infection and replication, and
allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
This is the 13th of 106 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001.
53 studies are RCTs, which show efficacy with p=0.000000087.
This study is excluded in the after exclusion results of meta
analysis:
concern about potential data issues.
Study covers iota-carrageenan and ivermectin.
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risk of case, 96.3% lower, RR 0.04, p < 0.001, treatment 0 of 131 (0.0%), control 11 of 98 (11.2%), NNT 8.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
2.
doyourownresearch.substack.com, doyourownresearch.substack.com/p/the-potemkin-argument-part-vii-together.
3.
Aref et al., Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia, Infection and Drug Resistance, doi:10.2147/IDR.S381715.
4.
Aref (B) et al., Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19, International Journal of Nanomedicine, doi:10.2147/IJN.S313093.
5.
Chahla et al., Intensive Treatment With Ivermectin and Iota-Carrageenan as Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From Tucuman, Argentina, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001433.
Carvallo et al., 19 Oct 2020, prospective, Argentina, preprint, 1 author, dosage 1mg days 1-14, this trial uses multiple treatments in the treatment arm (combined with iota-carrageenan) - results of individual treatments may vary, see notes, trial NCT04425850 (history).
