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c19early.org COVID-19 treatment researchP2Y12P2Y12 (more..)
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ REMAP-CAP Bradbury (RCT) 19% 0.81 [0.67-0.98] death 165/563 170/521 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Late treatment 19% 0.81 [0.67-0.98] 165/563 170/521 19% lower risk All studies 19% 0.81 [0.67-0.98] 165/563 170/521 19% lower risk 1 P2Y12 COVID-19 study c19early.org June 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Effect extraction pre-specified(most serious outcome) Favors P2Y12 Favors control
Mar 22
2022
Bradbury et al., JAMA, doi:10.1001/jama.2022.2910 Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial
19% lower mortality (p=0.03). RCT 1,557 critical patients, showing significantly lower mortality with aspirin, with 97.5% posterior probability of efficacy.
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