Ursodeoxycholic acid for COVID-19: real-time meta-analysis of 21 studies (Version 19)

Significantly lower risk is seen for progression, recovery, and cases. 13 studies from 12 independent teams in 4 countries show significant benefit.

Meta-analysis using the most serious outcome reported shows 19% [-3‑36%] lower risk, without reaching statistical significance. Results are similar for higher quality and peer-reviewed studies.

Control UDCA

No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Other treatments are more effective. UDCA currently has no early treatment studies. Administration with a meal increases the bioavailability of ursodeoxycholic acid. All data and sources to reproduce this analysis are in the appendix.

Yu et al. present another meta-analysis for ursodeoxycholic acid, showing significant improvement for severity.