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Spironolactone for COVID-19: real-time meta analysis of 11 studies

Covid Analysis (Preprint) (meta analysis)
Covid Analysis, Spironolactone for COVID-19: real-time meta analysis of 11 studies, (Preprint) (meta analysis)
Jun 2023   Source   PDF  
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• Statistically significant improvements are seen for mortality, progression, and recovery. 10 studies from 9 independent teams in 8 different countries show statistically significant improvements in isolation (8 for the most serious outcome).
• Meta analysis using the most serious outcome reported shows 36% [17‑51%] improvement. Results are similar for Randomized Controlled Trials, similar after exclusions, and slightly worse for peer-reviewed studies. Early treatment is more effective than late treatment.
• No treatment, vaccine, or intervention is 100% effective and available. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. None of the spironolactone studies show zero events with treatment.
• All data to reproduce this paper and sources are in the appendix.
Percentage improvement with spironolactone (more)
Early treatmentLate treatmentAll studiesStudies Patients Authors
All studies77% [34‑92%]**52% [21‑71%]**36% [17‑51%]** 1128,019 97
Randomized Controlled TrialsRCTs-44% [-14‑73%]44% [-14‑73%] 3324 49
Mortality-48% [24‑64%]***34% [5‑54%]* 325,206 20
HospitalizationHosp.-52% [-95‑88%]52% [-95‑88%] 2272 29
Cases--51% [-92‑87%] 20 12
Covid Analysis et al., Jun 2023, preprint, 1 author.
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Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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