Significantly lower risk is seen for mortality, hospitalization, progression, and recovery. 10 studies from 7 independent teams (all from the same country) show significant benefit.
Meta analysis using the most serious outcome reported shows 55% [30‑72%] lower risk. Results are similar for higher quality studies and worse for Randomized Controlled Trials.
Results are robust — in exclusion sensitivity analysis 6 of 12 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
Control Regdanvimab
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2, BA.4, BA.51, ХВВ.1.9.1, XBB.1.9.3, XBB.1.5.24, XBB.1.16, XBB.2.9, BQ.1.1.45, CL.1, and CH.1.12. mAb use may create new variants that spread globally3-5, and may be associated with prolonged viral loads, clinical deterioration, and immune escape4,6-8.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. All data and sources to reproduce this analysis are in the appendix.
Covid Analysis et al., Jul 2025, preprint, 1 author.
