Statistically significant lower risk is seen for mortality, hospitalization, and cases. 11 studies from 11 independent teams in 8 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 25% [14‑35%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies.
Results are very robust — in exclusion sensitivity analysis 16 of 24 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments are more effective.
All data to reproduce this paper and sources are in the appendix. Alam et al. present another meta analysis for N-acetylcysteine, showing significant improvement for mortality.
Covid Analysis et al., Oct 2024, preprint, 1 author.
