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c19early.org COVID-19 treatment researchBebtelovimabBebtelovimab (more..)
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All Studies   Meta Analysis       

Bebtelovimab for COVID-19: real-time meta analysis of 6 studies

Covid Analysis
Mar 2025  
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Meta analysis using the most serious outcome reported shows 34% [-24‑65%] lower risk, without reaching statistical significance. Results are similar for peer-reviewed studies and worse for Randomized Controlled Trials. 2 studies from 2 independent teams (both from the same country) show significant benefit.
Currently there is limited data, with only 34 control events for the most serious outcome in trials to date.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BQ.1.11, BA.5, BA.2.75, XBB, XBB.1.5, XMM.1.9.12,3. mAb use may create new variants that spread globally4,5, and may be associated with prolonged viral loads, clinical deterioration, and immune escape5-8.
Prescription treatments have been preferentially used by patients at lower risk9. Retrospective studies may overestimate efficacy, for example patients with greater knowledge of effective treatments may be more likely to access prescription treatments but result in confounding because they are also more likely to use known beneficial non-prescription treatments.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Other treatments are more effective. All data and sources to reproduce this analysis are in the appendix.
Covid Analysis et al., Mar 2025, preprint, 1 author.
This PaperBebtelovimabAll
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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