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All Studies   Meta Analysis       

Vitamin B9 for COVID-19: real-time meta analysis of 16 studies (11 treatment studies and 5 sufficiency studies)

Covid Analysis
Dec 2024  
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Meta analysis using the most serious outcome reported shows 11% [-15‑47%] higher risk, without reaching statistical significance.
5 sufficiency studies analyze outcomes based on serum levels, showing 20% [5‑33%] lower risk for patients with higher vitamin B9 levels.
Results to date are contradictory. Several studies show higher mortality, however counfounding by indication may be significant — patients prescribed folic acid may have significantly higher risk on average. Studies independent of prescriptions based on patient condition show positive results1,2, as do sufficiency studies. Folic acid may not be the most effective or safest form for supplementation3. Studies show that a significant fraction of people have genetic variations limiting the ability to convert folic acid to the active form.
All data and sources to reproduce this analysis are in the appendix.
Covid Analysis et al., Dec 2024, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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