Vitamin B9 for COVID-19: real-time meta analysis of 18 studies (12 treatment studies and 6 sufficiency studies)

Meta analysis using the most serious outcome reported shows 8% [-18‑41%] higher risk, without reaching statistical significance.

6 sufficiency studies analyze outcomes based on serum levels, showing 22% [7‑34%] lower risk for patients with higher vitamin B9 levels.

Control Vitamin B9

Results to date are contradictory. Several studies show higher mortality, however counfounding by indication may be significant — patients prescribed folic acid may have significantly higher risk on average. Studies independent of prescriptions based on patient condition show positive results1,2, as do sufficiency studies. Folic acid may not be the most effective or safest form for supplementation3. Studies show that a significant fraction of people have genetic variations limiting the ability to convert folic acid to the active form.

All data and sources to reproduce this analysis are in the appendix.