Meta analysis shows 24% [9‑40%] higher mortality, and pooled analysis using the most serious outcome reported shows 28% [17‑41%] higher risk.
1 RCT with 600 patients has not reported results (8 months late) Marcy.
Concerns have been raised over the use of acetaminophen (paracetamol) for COVID-19 Pandolfi, Sestili. Studies show significantly increased risk.
Potential mechanisms of harm include glutathione depletion, fever suppression, liver toxicity, immunosuppression, cytokine disruption, prostaglandin inhibition, COX inhibition, cell/tissue injury, mitochondrial dysfunction, glycine depletion, disruption of redox balance, increased oxidative stress, trace mineral depletion, microbiome alteration, and endocannabinoid system dysfunction.
All data to reproduce this paper and sources are in the appendix. Acetaminophen is also known as paracetamol.
Acetaminophen is also known as paracetamol, Tylenol, Panadol, Calpol, Tempra, Calprofen, Doliprane, Efferalgan, Grippostad C, Dolo, Acamol, Fevadol, Crocin, and Perfalgan.
Covid Analysis et al., Apr 2024, preprint, 1 author.
