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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Recovery, day 30 67% Improvement Relative Risk Recovery, day 15 57% Recovery, day 10 41% Recovery, day 5 24% Vitamin A  Mahjoub et al.  EARLY TREATMENT  DB RCT Is early treatment with melatonin, zinc, vitamins A-E beneficial for COVID-19? Double-blind RCT 164 patients in Tunisia (January - February 2023) Improved recovery with melatonin, zinc, vitamins A-E (not stat. sig., p=0.32) c19early.org Mahjoub et al., Explore, June 2023 Favors vitamin A Favors control

Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: a prospective, randomized, double-blind multicenter study.

Mahjoub et al., Explore, doi:10.1016/j.explore.2023.06.009
Jun 2023  
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RCT 164 low-risk (no hospitalizations) patients in Tunisia, showing improved recovery with zinc, melatonin, and vitamins A-E. This study includes COVID-19 and COVID-like illness, with 49% of 128 patients receiving a PCR test being COVID-19 PCR+ at baseline.
25mg zinc, 2mg melatonin, 40mg vitamin C, 2.5mcg vitamin D, 10mcg provitamin A, 0.65mg vitamin B1, 0.7mg B2, 8mg B3, 3mg B5, 0.7mg B6, 25mcg B8, 100mcg B9, 1.25mcg B12, and 6mg vitamin E daily.
This study includes melatonin, zinc, vitamin A, vitamin C, and vitamin D.
risk of no recovery, 66.7% lower, RR 0.33, p = 0.32, treatment 0 of 82 (0.0%), control 1 of 82 (1.2%), NNT 82, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 30.
risk of no recovery, 57.1% lower, RR 0.43, p = 0.05, treatment 6 of 82 (7.3%), control 14 of 82 (17.1%), NNT 10, day 15.
risk of no recovery, 40.7% lower, RR 0.59, p = 0.04, treatment 16 of 82 (19.5%), control 27 of 82 (32.9%), NNT 7.5, day 10.
risk of no recovery, 24.1% lower, RR 0.76, p = 0.04, treatment 44 of 82 (53.7%), control 58 of 82 (70.7%), NNT 5.9, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mahjoub et al., 20 Jun 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, peer-reviewed, 15 authors, study period 2 January, 2023 - 4 February, 2023, this trial uses multiple treatments in the treatment arm (melatonin, zinc, vitamins A-E) - results of individual treatments may vary.
Contact: jaballahrahma27@gmail.com, mhjoub.lobna@gmail.com, rymm.youssef@gmail.com, hajermedecin@gmail.com, bensalah.houda2@gmail.com, mejrimouez@gmail.com, adel.sekma@gmail.com, imentrabelsi@hotmail.fr, semir.nouira.urg@gmail.com, mariemkhrouf@yahoo.fr, bensoltanehouda@yahoo.fr, ziedmezgar@gmail.com, lotfibk@hotmail.fr, asmazorgati@yahoo.fr, riadboukef@gmail.com.
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This PaperVitamin AAll
Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: a prospective, randomized, double-blind multicenter study.
Lobna Mahjoub, MD Rym Youssef, MD Hajer Yaakoubi, Houda Ben Salah, MD Rahma Jaballah, MD Moez Mejri, MD Adel Sekma, MD Imen Trabelsi, Semir Nouira, MD Mariem Khrouf, MD Houda Ben Soltane, MD Zied Mezgar, MD Lotfi Boukadida, MD Asma Zorgati, MD Riadh Boukef
EXPLORE, doi:10.1016/j.explore.2023.06.009
Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: a prospective, randomized, double-blind multicenter study.
Conclusion: Among non-hospitalized patients presenting to the emergency department with Covid-19 and Covid-like illness, daily doses of Melatonin, zinc and multivitamin compared with placebo, did significantly reduce the duration of symptoms accelerating its disappearance without developing complications or necessitating hospitalization or experiencing adverse events . The findings do support the use of this association for the treatment of COVID-19.
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