Mar 3 2023 |
et al., eClinicalMedicine, doi:10.1016/j.eclinm.2023.101889 | Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial |
| 6% higher mortality (p=0.79) and 18% worse recovery (p=0.35). RCT severe COVID-19 patients showing no significant difference in outcomes with icatibant. | ||
Jan 4 2023 |
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac984 | Three-Day Icatibant on Top of Standard Care in Patients With Coronavirus Disease 2019 Pneumonia: A Randomized, Open-Label, Phase 2, Proof-of-Concept Trial |
| 47% lower mortality (p=0.01), 46% higher hospital discharge (p=0.01), and 41% lower need for oxygen therapy (p=0.03). RCT 77 hospitalized COVID-19 pneumonia patients requiring supplemental oxygen, showing reduced oxygen requirements, hospital stay, and mortality with icatibant treatment compared to standard care alone. | ||
Feb 16 2021 |
et al., Viruses, doi:10.3390/v13020309 | Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19 |
| 67% lower mortality (p=1) and 5% lower hospital discharge (p=0.89). RCT 30 severe COVID-19 patients showing no significant difference in mortality or hospitalization time with kinin-kallikrein system inhibitors icatibant or iC1e/K. While there was no impact on mortality or hospitalization time, both treat.. | ||
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