Significantly lower risk is seen for mortality, progression, recovery, and viral clearance. 11 studies from 10 independent teams in 8 countries show significant benefit.
Meta analysis using the most serious outcome reported shows 49% [36‑59%] lower risk. Results are similar for Randomized Controlled Trials and peer-reviewed studies. Early treatment is more effective than late treatment.
Results are very robust — in exclusion sensitivity analysis 13 of 14 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
Control Alkalinization
SARS-CoV-2 requires acidic pH for endosomal entry1. Alkalinization of the respiratory mucosa may reduce risk. Studies to date typically use sodium bicarbonate.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. We also present an analysis focusing on sodium bicarbonate2. Alkalinization may affect the natural microbiome, especially with prolonged use. All data and sources to reproduce this analysis are in the appendix.
Shafiee et al. present another meta analysis for alkalinization, showing significant improvements for mortality and recovery.
Covid Analysis et al., May 2025, preprint, 1 author.
