Statistically significant lower risk is seen for mortality, hospitalization, progression, recovery, and viral clearance. 9 studies from 8 independent teams in 8 countries show statistically significant improvements.
Meta analysis using the most serious outcome reported shows 49% [32‑61%] lower risk. Results are similar for Randomized Controlled Trials and peer-reviewed studies. Early treatment is more effective than late treatment.
Results are robust — in exclusion sensitivity analysis 9 of 11 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
SARS-CoV-2 requires acidic pH for fusion Kreutzberger. Alkalinization of the respiratory mucosa may reduce risk. Treatments investigated to date typically use sodium bicarbonate.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. Alkalinization may affect the natural microbiome, especially with prolonged use.
All data to reproduce this paper and sources are in the appendix.
Covid Analysis et al., Mar 2024, preprint, 1 author.